甲巯咪唑联合雷公藤多苷治疗甲亢患者的疗效及安全性研究

Efficacy and Safety of methimazole joint tripterygium glycosides treat patients with hyperthyroidism

目的:总结探讨甲巯咪唑与雷公藤多苷联合用药治疗甲亢的临床疗效及用药安全性。方法:收治甲亢患者90例,随机分为观察组和对照组,各45例,对照组给予甲巯咪唑治疗,观察组给予甲巯咪唑联合雷公藤多苷治疗,观察比较两组患者的临床疗效、TSH变化、不良反应情况等。结果:观察组治疗总有效率97.8%明显高于对照组的86.7%(P<0.05);观察组治疗后TSH水平明显高于对照组(P<0.05)。结论:和甲巯咪唑单独用药治疗相比,与雷公藤多苷联合用药治疗甲亢疗效更佳,且用药安全。

Objective:To discuss the efficacy and safety of methimazole joint tripterygium glycosides treat patients with hyperthyroidism.Methods:90 patients with hyperthyroidism were selected,they were randomly divided into the observation group and the control group with 45 cases in each.The control group were given methimazole treatment,the observation group given methimazole combined with tripterygium glycosides treatment.The clinical efficacy,TSH changes,adverse reactions of the two groups were observed and compared.Results:The total effective rate of the observation group was 97.8%significantly higher than that in the control group of 86.7%(P<0.05),the TSH level in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Compareing with the single drug treatment with methimazole,tripterygium glycosides combined with drugs in the treatment of hyperthyroidism has better curative effect,and drug safety.