干扰素治疗EV71手足口病脑炎临床效果观察

Clinical effect observation of interferon in the treatment of EV71 hand foot mouth disease encephalitis

目的:观察干扰素治疗小儿EV71手足口病脑炎的临床效果,探讨临床有效治疗方案。方法:收治EV71手足口病脑炎患儿60例,随机分为治疗组31例和对照组29例。对照组给予对症支持治疗,治疗组在对照组的基础上给予干扰素治疗。比较两组患儿的临床效果。结果:治疗组退热时间、手足疱疹消退时间、口腔溃疡愈合时间和平均住院时间明显短于对照组(P<0.05)。治疗组临床疗效优于对照组(P<0.05)。结论:干扰素治疗小儿EV71手足口病脑炎具有显著的疗效,应考虑作为常规治疗方法。

Objective:To observe the clinical effect of interferon in the treatment of children EV71 hand foot mouth disease encephalitis,to explore the clinical effective treatment plan.Methods:60 children with EV71 hand foot mouth disease encephalitis were selected.They were randomly divide into the treatment group with 31 cases and the control group with 29 cases.The control group were given symptomatic and supportive treatment.The treatment group were given interferon treatment on the basis of the control group.The clinical effects of the children in two groups were compared.Results:The fever subsidence time,hand foot herpes regression time,oral ulcer healing time and the average hospitalization time of the treatment group were significantly shorter than those of the control group(P<0.05).The clinical curative effect of the treatment group was better than that of the control group(P<0.05).Conclusion:Interferon in the treatment of children EV71 hand foot mouth disease encephalitis has a significant curative effect.It should be considered as a conventional treatment.