局部应用氨甲环酸减少初次单侧全膝关节置换术后失血量的临床研究

Clinical research of local application of tranexamic acid to reduce the blood loss after primary unilateral total knee arthroplasty

目的:探讨局部应用氨甲环酸对初次单侧全膝关节置换术出血量的影响。方法:收治骨性关节炎行单侧全膝关节置换术患者68例,分为两组各34例:A组:局部灌注氨甲环酸,B组:局部灌注生理盐水。结果:A组与B组相比较,术后24 h、48 h引流量以及术后48 h血红蛋白量、血红蛋白下降百分比差异均具有统计学意义(P<0.05)。结论:在全膝关节置换术中局部应用氨甲环酸能明显减少患者失血量,且不增加静脉血栓形成的风险。

Objective:To investigate the effects of topical application of tranexamic acid for the blood loss after primary unilateral total knee arthroplasty.Methods:68 patients with osseous arthritis who had unilateral total knee arthroplasty were selected,they were divided into two groups with 34 cases in each:the A group:infusion of tranexamic acid,the B group:local perfusion of saline.Results:The A group compared with the B group,the difference of the postoperative 24 h,48h lead traffic and the postoperative 48 h hemoglobin,hemoglobin decreased rate had statistically significant(P<0.05).Conclusion:The topical application of tranexamic acid in total knee arthroplasty can decrease blood loss significantly and does not increase the risk of venous thrombosis.