立体定向放射治疗和手术治疗肺癌预后比较的Meta分析

Meta analysis of the prognosis comparison of stereotactic radiotherapy and operative treatment in lung cancer

目的:探讨立体定向放射(SBRT)治疗和手术治疗肺癌预后Meta分析。方法:以"立体定向放射治疗""肺癌""Ⅰ期非小癌细胞"等为检索词,搜索近20年SBRT手术治疗肺癌的预后临床分析,根据Cochrance评价法,由两名评价人提出数据,按照NOS量表评估检索文献质量,在运用Revman5.0做Meta分析。结果:符合标准的文献8篇,SBRT组病例数348例,手术组712例,Meta分析结果显示,手术组患者分别2、3、5年的存活率均高于SBRT组患者(P<0.05)。结论:对于肺癌的治疗,SBRT治疗方式在总存活率上低于手术治疗方式,但仍不能得出手术方法优于SBRT方法的结论,两种方法的疗效仍需要进一步临床验证。

Objective:To explore the Meta analysis of the prognosis of stereotactic radiotherapy(SBRT) and operation treatment in lung cancer.Methods:The stereotactic radiotherapy,lung cancer,Ⅰ stage non-small cancer cells were as the index words,searching the prognosises of SBRT operative treatment for lung cancer in recent 20 years were clinically analyzed.According to the Cochrance evaluation method,the data were evaluated by two reviewers,the searching literature quality was assessed by the NOS scale,and the Meta analysis was done by Revman5.0.Results:The documents according with the standard were 8 pieces.The cases in the SBRT group were 348 cases,the operation group were 712 cases.The Meta analysis result showed that the survival rate of 2, 3 and 5 years of patients in the operation group were higher than those of the SBRT group(P<0.05).Conclusion:For the treatment of lung cancer,the total survival rate of SBRT treatment was lower than that of the operation treatment,but it still can not reach the conclusion that the operation method is better than the SBRT method,the curative effects of the two treatments still need to be further clinical verification.