培美曲塞或紫杉醇联合顺铂治疗晚期肺腺癌的近期疗效比较

Comparison of the short-term curative effect of pemetrexed or paclitaxel combined with cisplatin in the treatment of advanced lung adenocarcinoma

目的:对比培美曲塞或紫杉醇联合顺铂治疗晚期肺腺癌的近期疗效以及不良反应。方法:收治Ⅲ~Ⅳ期肺腺癌患者40例,随机分成对照组和观察组各20例,经过2个周期的化疗后,对两组患者的疗效进行评定。结果:观察组总有效率90%,明显优于对照组的70%(P<0.05)。观察组患者的恶心、呕吐,白细胞减少发生率低于对照组(P<0.05)。两组患者的血小板减少、贫血、肝肾功能损害发生率比较,差异具有统计学意义(P<0.05)。结论:对于晚期肺腺癌采用培美曲塞联合顺铂治疗效果良好,并且不良反应比较轻。

Objective:To compare the short-term curative effect and adverse reaction of pemetrexed or paclitaxel combined with cisplatin in the treatment of advanced lung adenocarcinoma.Methods:40 patients with lung adenocarcinoma in Ⅲ ~Ⅳ period were selected.They were randomly divided into the control group and the observation group with 20 cases in each.After 2 cycles of chemotherapy,the curative effects of patients in two groups were assessed.Results:The total effective rate(90%) of the observation group was significantly better than 70% of the control group(P<0.05).The incidence rates of nausea and vomiting,leukopenia in the observation group were lower than those of the control group(P<0.05).The incidence rates of thrombocytopenia,anemia,liver and kidney function damage were compared,the difference was statistically significant(P<0.05).Conclusion:The treatment effect of using pemetrexed combined with cisplatin for advanced lung adenocarcinoma is good,and the adverse reactions are mild.