多西他赛联合顺铂与吉西他滨联合顺铂同期治疗鼻咽癌不良反应比较

Adverse reaction comparison of docetaxel combined with cisplatin and gemcitabine combined with cisplatin in the concurrent treatment of carcinoma of nasopharynx

目的:探讨多西他赛联合顺铂与吉西他滨联合顺铂同期治疗鼻咽癌不良反应的差异。方法:收治鼻咽癌患者60例,随机分成多西他赛组和吉西他滨组。多西他赛组给予顺铂联合多西他赛治疗,吉西他滨组给予顺铂联合吉西他滨治疗,比较两组不良反应发生情况。结果:多西他赛组不良反应26例,吉西他滨组不良反应28例,两组比较,差异无统计学意义(P>0.05)。结论:多西他赛联合顺铂与吉西他滨联合顺铂同期治疗鼻咽癌不良反应发生情况差异不大,均可作为治疗鼻咽癌的有效方案。

Objective:To investigate the adverse reaction difference between docetaxel combined with cisplatin and gemcitabine combined with cisplatin in the concurrent treatment of carcinoma of nasopharynx.Methods:60 cases of patients with carcinoma of nasopharynx were divided into the docetaxel group and the gemcitabine group randomly.The docetaxel group were treated with docetaxel combined with cisplatin and the gemcitabine group were given gemcitabine combined with cisplatin,the adverse reactions of the two groups were compared.Results:There were 26 cases of adverse reactions in the docetaxel group and 28 cases of adverse reaction in the gemcitabine group,there was no statistically significant difference of adverse reaction between the two groups(P>0.05).Conclusion:There was no significant difference of adverse reaction between docetaxel combined with cisplatin and gemcitabine combined with cisplatin in the concurrent treatment of carcinoma of nasopharynx,both of which could be as the effective treatment for carcinoma of nasopharynx.