心肌肌钙蛋白I和心型脂肪酸结合蛋白H-FABP联合检测对手足口病患儿心肌损伤的诊断价值

Diagnostic value of joint detection of serum cardiac troponin I and H-FABP in children with hand-foot-mouth disease combined myocardial injury

目的:探讨联合检测心肌肌钙蛋白I(c Tn I)和心型脂肪酸结合蛋白(H-FABP)对手足口病患儿心肌损伤的诊断价值。方法:将HFMD患儿198例分为心肌损伤组(42例)和心肌正常组(156例),52例健康儿童作为正常对照,检测各组入院第6、12、18、24、30、36 h血清H-FABP、c Tn I。结果:与心肌正常组和对照组比较,心肌损伤组c Tn I入院第12、18、24 h明显升高(P<0.05),H-FABP入院第6、12、18 h明显升高(P<0.05)。结论:血清H-FABP诊断HFMD患儿早期心肌损伤优于c Tn I。

Objective:To investigate the diagnostic value of joint detection of serum cardiac troponin I and H-FABP in children with hand-foot-mouth disease combined myocardial injury.Methods:198 cases of children with HFMD were divided myocardial injury group(42 cases) and no-myocardial injury group(156 cases) and 52 cases of healthy children as the control group,the serum H-FABP and cardiac troponin I of the three groups in the 6,12,18,24,30,36 hour after admission were detected.Results:Compared with no-myocardial injury group and the control group,the cTnI levels of the myocardial injury group increased more in 12,18,24 hour after admission,the H-FABP levels increased more in 6,12,18 hour after admission(P<0.05).Conclusions:The serum H-FABP had better diagnosis of early myocardial injury in children with HFMD than cTnI.