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非酒精性脂肪性肝病与心血管疾病机制的研究进展

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摘要 近年来,非酒精性脂肪性肝病(NAFLD)在世界范围内越来越受到关注,其定义为除酒精和其他明确的肝损伤因素所致的、以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征[1]。NAFLD为一系列进展性疾病谱,包括单纯性脂肪变、脂肪性肝炎、肝硬化[2],被认为是代谢综合征在肝脏的表现,同时与心血管疾病(C V D)也有密切关系[3]。关于NAFLD与CVD的相关性有许多流行病学报道,本文就N A F L D作为C V
作者 王海丽 占玉仙 赵小梅
机构地区 浙江象山县第一人民医院外科门诊 浙江大学医学院附属第一医院外科门诊
出处 《中国乡村医药》 2014年第13期78-79,74,共3页
关键词 心血管疾病 代谢综合征 脂肪性肝炎 进展性疾病 肝损伤 肝细胞 胰岛素抵抗 弥漫性 脂代谢紊乱 脂代
分类号 R575.5 [医药卫生—消化系统] R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献7

  • 1Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Chisato Nagata,Jun Takeda,Hiroshi Sarui,Yutaka Kawahito,Naohisa Yoshida,Atsushi Suetsugu,Takahiro Kato,Junichi Okuda,Kazunori Ida,Toshikazu Yoshikawa.Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease[J].World Journal of Gastroenterology,2007,13(10):1579-1584. 被引量：55
  • 2Naim Alkhouri,Tarek Abu-Rajab Tamimi,Lisa Yerian,Rocio Lopez,Nizar N. Zein,Ariel E. Feldstein.The Inflamed Liver and Atherosclerosis: A Link Between Histologic Severity of Nonalcoholic Fatty Liver Disease and Increased Cardiovascular Risk[J].Digestive Diseases and Sciences.2010(9)
  • 3G. Targher,F. Marra,G. Marchesini.Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?[J].Diabetologia.2008(11)
  • 4Anna Ludovica Fracanzani,Larry Burdick,Sara Raselli,Paola Pedotti,Liliana Grigore,Gennaro Santorelli,Luca Valenti,Alessandra Maraschi,Alberico Catapano,Silvia Fargion.Carotid Artery Intima-media Thickness in Nonalcoholic Fatty Liver Disease[J].The American Journal of Medicine.2008(1)
  • 5G. Targher,L. Bertolini,S. Rodella,G. Zoppini,G. Lippi,C. Day,M. Muggeo.Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients[J].Diabetologia.2008(3)
  • 6Jeremy P. Domanski,Stephen J. Park,Stephen A. Harrison.Cardiovascular Disease and Nonalcoholic Fatty Liver Disease: Does Histologic Severity Matter?[J].Journal of Clinical Gastroenterology.2012(5)
  • 7Maria Stepanova,Zobair M. Younossi.Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population[J].Clinical Gastroenterology and Hepatology.2012(6)

二级参考文献29

  • 1[1]Neuschwander-Tetri BA,Caldwell SH.Nonalcoholic steatohepatitis:summary of an AASLD Single Topic Conference.Hepatology 2003; 37:1202-1219
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中国乡村医药
2014年 第13期

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