冠心病合并2型糖尿病患者胃饥饿素/肥胖抑制素比值变化及其与冠脉病变的关系被引量：1

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摘要目的观察冠心病合并2型糖尿病患者胃饥饿素(Ghrelin)/肥胖抑制素(Obestatin)比值变化及其与冠状动脉病变程度的关系。方法该院心血管内科收治的108例冠心病患者,根据是否合并2型糖尿病分为单纯冠心病组57例与合并糖尿病组51例。测定两组血清Ghrelin、Obestatin水平,采用冠脉狭窄程度(Gensini)积分评估冠脉病变程度,分析Ghrelin/Obestatin比值与冠脉病变程度的相关性。结果合并糖尿病组的Ghrelin/Obestatin比值低于单纯冠心病组,Gensini积分明显高于单纯冠心病组,合并糖尿病组的Ghrelin/Obestatin比值与Gensini积分、糖化血红蛋白(Hb A1c)呈负相关,差异均有统计学意义。结论冠心病合并2型糖尿病患者的Ghrelin/Obestatin比值与冠状动脉病变程度密切相关,Ghrelin/Obestatin比值有可能作为预测冠心病合并2型糖尿病的预测指标之一。

作者史懿严爱芬吴伟萍

机构地区浙江余姚市人民医院检验科

出处《中国乡村医药》 2016年第16期62-63,共2页

关键词冠心病 2型糖尿病胃饥饿素/肥胖抑制素比值冠状动脉病变程度

分类号 R541.4 [医药卫生—心血管疾病] R587.1 [医药卫生—内分泌]

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参考文献3

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二级参考文献6

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