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应重视帕金森病早期诊断和运动并发症的防治 被引量:6

Pay attention to the early diagnosis of Parkinson's disease and prevention of its motor complications
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摘要 帕金森病是一类以黑质多巴胺能神经元选择性、渐进性大量变性、缺失,黑质纹状体多巴胺能通路变性为主要病理改变的神经系统变性疾病[12]。Fearnley和Lees[3]提出黑质多巴胺能神经元呈现指数级缺失的假设,即有近90%的黑质多巴胺能神经元在疾病亚临床期可能已经死亡。
出处 《中国现代神经疾病杂志》 CAS 2013年第7期551-554,共4页 Chinese Journal of Contemporary Neurology and Neurosurgery
关键词 帕金森病 早期诊断 运动障碍 综述 Parkinson disease Early diagnosis Movement disorders Review
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  • 1胡平,陈玲,张海琴,黎锦如,梁宏.Single photon emission computer tomography of dopamine transporters in monkeys and humans with ^(99m)Tc-TRODAT-1[J].Chinese Medical Journal,2004(7):1056-1059. 被引量:10
  • 2Drouot X, Oshino S, Jarraya B, et al. Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. Neuron, 2004, 44:769-778.
  • 3Benvenuti E, Cecchi F, Colombini A, et al. Extradural motor cortex stimulation as a method to treat advanced Parkinson's disease: new perspectives in geriatric medicine. Aging Clin Exp Res, 2006, 18:347-348.
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  • 6Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA, 2008, 105:5856-5861.
  • 7Kaplitt MG, Feigin A, Tang C, et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase Ⅰ trial. Lancet, 2007, 369:2097-2105.
  • 8Volz TJ, Farnsworth SJ, Rowley SD, et al. Age- dependent differences in dopamine transporter and vesicular monoautine transporter 2 function and their implications for methamphetamine neurotoxicity. Synapse, 2009, 63:147-151.
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