帕金森病运动并发症发生机制的研究进展

The potential mechanisms for motor complications of Parkinson's disease

帕金森病是临床常见的中枢神经系统变性疾病,拟多巴胺类药物仍是其主要治疗手段。帕金森病患者长期接受多巴胺替代治疗后,可出现运动并发症,发生机制目前尚未完全阐明,而且对有些运动并发症仍缺乏有效的治疗方法,给帕金森病的治疗带来了困难和挑战。近年来,国内外学者对帕金森运动并发症的发生机制进行了广泛的研究,取得了显著进展,本文拟从左旋多巴药代动力学及药效学、神经生化学等角度阐述导致运动并发症的相关机制,以期为后续帕金森运动并发症的机制及治疗相关研究提供新视野。

Parkinson's disease (PD) is a common neurodegenerative disease. Dopaminergic replacement therapy is still considered as a major treatment for PD. However, long term dopaminergic replacement therapy for PD patients is frequently associated with the development of motor complications. To date, the mechanisms underlying motor complications have not been completely understood yet. Moreover, parts of motor complications are lack of therapeutic alternatives. All these characters make this disorder difficult and challenging to manage. Increasing number of researches have been proposed in recent years for elucidating the underlying mechanisms of levodopa related motor complications, resulting in much progression. For better understanding the management of motor complications, here we provide an overview of the current knowledge of the potential mechanisms, including the pharmacodynamic and pharmacokinetic mechanisms of levodopa and levodopa associated neurotransmitter systems.