帕金森病冲动控制障碍

Impulse control disorders in Parkinson's disease

冲动控制障碍是帕金森病十分常见的非运动症状,有13.61%的帕金森病患者可出现冲动控制障碍。其不同亚型呈不同临床表现,多与抑郁症、焦虑症、强迫症、寻求新刺激及易冲动等有关,严重影响帕金森病患者生活质量。近年来,大量研究为帕金森患者潜在的冲动控制障碍发生机制提供了理论基础,有助于预防冲动控制障碍的发生并优化治疗方案。本文拟就帕金森病冲动控制障碍的流行病学、危险因素、发病机制、诊断及治疗最新进展进行综述。

Impulse control disorders (ICDs) in Parkinson's disease (PD) are common with a frequency of 13.61% , which are associated with impaired functioning and with depressive, anxiety and obsessive symptoms, novelty seeking and impulsivity. These behaviors have a bad influence on PD patients in the quality of life. Different behavioral subtypes suggest pathophysiological differences. Recent large scale studies and converging findings are beginning to provide an understanding of mechanisms underlying ICDs in PD which can guide the prevention of these behaviors and optimize therapeutic approaches. This paper will take a review on the recent advances in the epidemiology, risk factors, pathophysiology, diagnosis and therapy of ICDs in PD.