阿托伐他汀治疗颅骨成形术后并发硬膜外积液的疗效观察

Effectiveness and safety of atorvastatin in treatment of epidual effusion after cranioplasty performed

目的 探讨阿托伐他汀治疗大骨窗数字化塑形钛网颅骨成形术后硬膜外积液的疗效。方法纳入2014年8月至2019年1月采用大骨窗数字化塑形钛网颅骨成形术后并发硬膜外积液患者共58例,采取扩容、改善微循环、营养神经等常规治疗(对照组,23例),在此基础上部分患者予阿托伐他汀治疗(阿托伐他汀组,35例),1个月后进行临床疗效评价,随访2~4个月记录硬膜外积液完全吸收时间。结果 阿托伐他汀组治疗总有效率高于对照组[91.43%(32/35)对56.52%(13/23);Z=-3.143,P=0.002]、硬膜外积液完全吸收时间短于对照组[(32.77±7.00)d对(40.30±13.22)d;t=-2.511,P=0.018]。结论 阿托伐他汀治疗大骨窗数字化塑形钛网颅骨成形术后硬膜外积液有效,具有促进硬膜外积液吸收、改善患者预后之功效。

Objective To investigate the effect of atorvastatin in the treatment of patients with epidual effusion after digital plastic titanium mesh cranioplasty.Methods A total of 58 patients with epidual effusion after digital plastic titanium mesh cranioplasty from August 2014 to January 2019 were randomly divided into control group(N=23)and atorvastatin group(N=35).Control group was given routine treatment,such as dilatation,improvement of microcirculation and nutritional nerve.Atorvastatin group was given atorvastatin therapy on the basis of routine treatment.The clinical efficacy of patients was evaluated after one month of treatment and the complete absorption time of epidual effusion in patients was recorded during the follow?up period from 2 to 4 months.Results The total effective rate of atorvastatin group was significantly higher than that of control group[91.43%(32/35)vs.56.52%(13/23);Z=?3.143,P=0.002].Compare with control group,the total absorption time of epidual effusion in atorvastatin group was significantly shorter[(32.77±7.00)d vs.(40.30±13.22)d;t=?2.511,P=0.018].Conclusions Atorvastatin can accelerate the absorption of epidual effusion and improve the prognosis after digital plastic titanium mesh cranioplasty.