基于VOSviewer的富血小板血浆研究热点主题分析

Analysis on the hotspot of the platelet-rich plasma based on VOSviewer

背景:富血小板血浆为自体全血经离心之后所得的血小板浓缩物,含有大量生长因子及蛋白质。血小板活化后能够释放多种生长因子,加快细胞增殖及分化,能有效促进组织修复,且富血小板血浆取材方便,制备简单,被广泛应用于临床各领域应用。国外对于富血小板血浆的研究开展已久,并取得一定的研究成果。目的:综述并分析国外关于富血小板血浆近5年的研究进展。方法:由第一作者用计算机检索PubMed数据库,检索词为"Plasma,Platelet-Rich,Platelet Rich Plasma,Platelet-RichPlasma",检索时限为2014至2018年。利用可视化工具VOSviewer对检索所得研究论文的题录信息进行深度挖掘,从年度发文量、国家发文量以及研究主题等方面对其展开讨论,利用软件生成的知识图谱直观展示国外富血小板血浆研究的热点主题。结果与结论:检索得到相关文献38篇。结果表明,国外近5年关于富血小板血浆的研究论文发表量逐年递增,美国发文量最多,通过进行共词聚类分析可知关于富血小板血浆的研究热点主要集中在以下5个方面:动物实验、骨关节科、细胞学实验、口腔科、慢性伤口。研究结果为中国富血小板血浆领域的研究方向及热点选择提供了参考。

BACKGROUND: Platelet-rich plasma is a platelet concentrate obtained from autologous whole blood after centrifugation, which contains a lot of growth factors and proteins. Activated platelets can release a variety of growth factors so as to accelerate cell proliferation and differentiation, and can effectively promote tissue repair.Platelet-rich plasma has been widely used in various clinical fields because of its convenient sampling and simple preparation. Overseas research on platelet-rich plasma has been carried out for a long time, and has achieved certain results.OBJECTIVE: To review the research advance of platelet-rich plasma at abroad in recent 5 years.METHODS: PubMed database was retrieved with the keywords of 'plasma, platelet-rich, platelet rich plasma,platelet-rich plasma’’ and the retrieval time was from 2014-2018. The visual tool VOSviewer was used to deeply search the title information of the papers retrieved. The annual and national published number, and research topics were discussed. The knowledge map generated by software is used to visually display the hotspot of platelet-rich plasma research at abroad.RESULTS AND CONCLUSION: Thirty-eight relevant articles were retrieved. The results show that in the past five years the number of papers published on platelet-rich plasma in foreign countries has increased year by year, and the United States has the largest number of publications. Through co-word clustering analysis, the hotspots of platelet-rich plasma are mainly concentrated on the following five aspects:animal experiments, orthopedics, cytology experiments, stomatology and chronic wounds. Research results provide reference for the direction and hotspot of research on platelet-rich plasma in China.