24h动态心电图检测QT间期缩短与变异型心绞痛患者室性心律失常的关系研究

Relationship between dynamic electrocardiographic QT interval shortening and ventricular arrhythmia in patients with variant angina pectoris

目的分析变异型心绞痛患者动态心电图QT间期缩短与室性心律失常的相关性。方法收集2010年4月至2018年4月嘉兴市秀洲区新塍医院行24h动态心电图检测的变异型心绞痛患者临床资料,根据变异型心绞痛发作时心电图校正QT间期是否缩短分成QT间期缩短组与正常组。比较两组患者的室性期前收缩负荷,室性心律失常、室性心动过速、晕厥或猝死的发生率、左心室射血分数(LVEF)。结果共纳入48例,其中QT间期缩短组21例,正常组27例。室性期前收缩负荷[(6.5±1.5)%]、发生室性心动过速、晕厥与室性心律失常的比例(38.1%、23.8%、61.9%)缩短组均明显高于正常组[(3.8±1.0)%、11.1%、3.7%、21.6%],LVEF为(31.8±1.3)%,低于对照组的(35.1±1.6)%,差异均有统计学意义(均P<0.05)。结论变异型心绞痛发作时QT间期缩短的患者发生室性心律失常的风险较高。

Objective To analyze the correlation between dynamic electrocardiographic QT interval shortening and ventricular arrhythmia in patients with variant angina pectoris.Methods The clinical data of patients with variant angina and underwent dynamic electrocardiographic monitoring from April 2010 to April 2018 were retrospectively analyzed.They were divided into QT interval shortening group and normal group based on whether corrected QT interval shortened or not.The ventricular premature contraction load,the incidence of ventricular arrhythmia,ventricular tachycardia,syncope or sudden death,and left ventricular ejection fraction were compared between the two groups.Results A total of 48 patients were enrolled with 21 in QT interval shortening group and 27 in normal group.The ventricular premature contraction load,the incidence of ventricular tachycardia,syncope and ventricular arrhythmia were significantly higher,and the left ventricular ejection fraction was significantly lower,in patients with QT interval shortening group[(6.5±1.5)%,38,1%,23.8%,61.9%,(31.8±1.3)%]than in normal group[(3.8±1.0)%,11.1%,3.7%,21.6%,(35.1±1.6)%](all P<0.05).Conclusion Patients with QT interval shortening during variant angina attacking have higher risk of ventricular arrhythmia.