塞隆骨对骨缺失大鼠的作用研究

The Action Of Sailong Bone In Bony Deficiency Rats

目的通过塞隆骨对大鼠骨缺损修复速度和骨质疏松症治疗作用的研究,探讨塞隆骨对骨缺失大鼠的强筋健骨作用。方法人为造成大鼠股骨缺损,观察塞隆骨对创口外观、新生骨厚度、荧光强度及显微改变的影响;另给大鼠饲喂低钙饲料,饮用去离子水,注射地塞米松引起骨质疏松症,观察塞隆骨对骨密度、骨灰分和骨钙含量的影响。结果塞隆骨组骨缺损区域损伤明显好转,新生骨较厚,骨质细胞分化明显,成熟,骨小梁一致,其骨损伤修复作用明显好于对照组;另外塞隆骨可明显增加骨质疏松大鼠骨密度,尤其对髂骨密度、腰椎密度增加更明显,同时可明显增加骨灰分和骨钙含量。结论塞隆骨有明显促进骨损伤大鼠的骨折愈合修复作用和治疗骨质疏松模型大鼠的骨质疏松症状的作用。

OBJECTIVE In order to probe into the action of Sailong bones strengthening the muscles and bones in bony deficiency rats,the restoration speed in bony deficiency rats and the therapeutic action in osteoporotic rats were studied.METHOD The femur coloboma was man-made so as to observe the Sailong boneS influence on wounds outward appearance,neogenesis bones thickness,fluorescence intensity and micro modification in rat.Besides,the models of osteoporosis in rats were caused by feeding hvpocalcia feed,drinking deinazated water and injecting dexamethasone,then the effect of Sailong bone on the bone density,bone ash and bone calcium content were observed in these rats.RESULTS the bone injury area taken a favourable turn,the neogenesis bone grew thicker,the sclerous cell differentiation was clear and mature,the bone trabecula was consistency,all these showed that Sailong bone had better effect obviously on the action of bone injury restoration in comparison with the control group.In addition to,Sailong bone could obviously increase the bone density in osteoporosis rats,special for ilium,lumbar vertebrae.The content of bone calcium and bone ash were also increased.CONCLUSION Sailong bone had the actions to promote the union in bony injury rats and to treat the osteoporosis in osteoporotic rats.