特非那定片溶出度测定(英文)

Determination Dissolution of six commercial terfenadine tablets

目的评价市场上6个批号的特非那定片的质量。方法采用桨法作为溶出度测定法,HPLC作为特非那定浓度测定方法,再通过weibull's方程获得溶出度参数。结果仅有2个批号的特非那定片达到卫生部部颁标准。结论我们应该关注市场上特非那定片的质量。

OBJECTIVE To evaluate the drug quality in vitro of six commercial terfenadine tablets.METHOD The initial dissolution rate were measured using rotating paddle method.HPLC-method was used to determine the concentration of terfenadine and the Weibulls equation to model the main dissolution parameters.RESULTS Only two of six batch terfenadine tablets met with the requirements of criterion of Ministry of public health.CONCLUSION Because of the significant difference in drug dissolution among six terfinadine tablets,it is indicated that more attention should be paid to their clinical use.