颅痛宁糖浆治疗特发性三叉神经痛的疗效观察

Lu Tong-Ning syrupus in treatment of patiens with idiopathic trigeminal neuralgia

目的观察颅痛宁糖浆治疗特发性三叉神经痛的疗效。方法特发性三叉神经痛983例,随机分为二组,颅痛宁组500例(男性232例,女性268例,年龄52a±s9a)给予颅痛宁糖浆50mL,po,bid;卡马西平组483例(男性225例,女性258例,年龄51a±8a),给予卡马西平0.1,po,tid。结果颅痛宁组总有效率91.8%;卡马西平组总有效率72.5%;组间疗效比较差别有显著意义(P<0.001)。结论颅痛宁糖浆安全有效,不良反应少,较卡马西平疗效显著。

OBJECTIVE To observe the effect of Lu Tong-Ning syrupus In treatment of idiopathic trigeminal neuragia.METHOD Nine hundred and eighty-three patients with idiopathic trigeminal neuragina were radomLy divided into two groups.The Lu Tong-Ning group of 500 patients(M232,F268;age52a ± s9a) were given Lu Tong-Ning syrupus 50 mL,po,bid;carbamazepine group of 483 patients(M225;F258;age51a ±8a) were given cabamazepine groupO.1,po,tid,The two groups showed the same therapeutic time as 30 d.RESULTS The total effective rats was 91.8%in Lu Tong-Ning syrupus group and 72.5%in Carbamazepine group;The differences were greatly significant(Ridit analysis P <0.001).CONCLUSION Lu Tong-Ning syrupus is a safe and effective drug than Carbamazepine in tereating idiopathic trigeminal neuragia,less adverse reactions were found.