人参皂苷对内皮细胞ECV304代谢NO的影响

The Effect of Ginsenosides on the NO Production in ECV304

目的探讨人参皂苷预防和治疗心血管疾病的机理。方法应用血清药理学方法研究了人参皂苷对常规培养正常内皮细胞和氧化损伤内皮细胞代谢一氧化氮(NO)的影响。结果人参皂苷可上调正常内皮细胞和氧化损伤内皮细胞NO的代谢,分别上调了3.98倍和6.04倍,差异显著(P<0.01)。结论人参皂苷可能通过升高内皮细胞NO的代谢,而对心血管疾病具有良好的防效和疗效。

OBJECTIVE to study the mechanism of Ginsenosides preventive and remedial effect on cardio-vascular diseases.METHOD The effect of Ginsenosides on the nitric oxide(NO) Production in normal ECV304 and oxidation injury ECV304 was studied with Serum Pharmacology.RESULTS Ginsenosides could up-regulate the NO production in normal ECV304 and oxidation injury ECV304 significantly(P <0.01) by 3.98 times and 6.02 times respectively.CONCLUSION Ginsenosides have the preventive and remedial effect on cardio-vascular diseases by increasing NO production in vascular endothelial cells.