摘要
目的研究地红霉素的合成工艺。方法以红霉素为原料,经与水合肼缩合,硼氢化钠还原,再与2-(2-甲氧基乙氧基)乙缩醛缩合得到地红霉素。结果该合成路线不仅收率高,产品纯,而且无需过柱分离。结论该工艺路线适合工业化生产。
OBJECTIVE To Study the synthetic technology of the dirithromycin.METHOD Dirithromycin was synthsized by condensation of euythromycin with hudrazine hydrate,reduction and condensation with 2-(2-methoxyethoxy)acetadehyde.RESULTS Yields and purity is satisfied,and does not need posts to be separated.CONCLUSION This procedure is suitable for industry production.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第S2期39-40,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
地红霉素
合成
红霉素
dirithromycin
synthesis
erythromycin
