盐酸左氧氟沙星凝胶的制备与质量控制

The Preparation of levofloxacin hydrochloride gel and qualilty Control

目的研制盐酸左旋氧氟沙星凝胶。方法用卡波姆-940作凝胶基质,制备盐酸左旋氧氟沙星凝胶,用紫外分光光度法测定其含量,并考察其稳定性。结果含量测定平均回收率99.96%,RSD=0.20%(n=6)。结论本方法设计合理,制备工艺简单,制备的凝胶稳定性好,具有应用方便,作用持久的特点,适于临床应用。

OBJECTIVE To prepare levofloxacin hydrochloride gel.METHOD Carbopol-940 was used as the gel stroma to prepare the gel of levofloxacin hydrochloride,assesy using UV method to analysis the content,and research stability of the preparation.RESULTS the average return rate of content assay was 99.96%,RSD = 0.20%(n = 6).CONCLUSION The method was designed reasonably,the preparation method was simple,stability of the preparation was good and can be used expediently,the action last long.It is applicable in clinic.