基于多指标权重分析和正交设计法优选复方必清颗粒的提取工艺

Exploration on Extraction Process of Compound Biqing Granules Based on Orthogonal Design and Multi-index Weight Analysis

目的确定指标权重,优选复方必清颗粒提取工艺,为其工业化生产提供参考。方法以薯蓣皂苷元、秋水仙碱、槲皮素含量和出膏率为评价指标,采用层次分析法(analytichierarchyprocess,AHP)、CRITIC法及AHP-CRITIC混合加权法确定各指标权重系数,结合正交试验结果优化复方必清颗粒提取工艺参数。结果 AHP-CRITIC混合加权法较AHP法和CRITIC法科学、合理、稳定,按照其确定的权重系数进行综合评价,确定复方必清颗粒的最佳提取工艺条件:加8倍量70%乙醇,提取2次,每次1.0 h。结论 AHP-CRITIC混合加权法确定的权重系数客观、真实,可以反映复方必清颗粒配伍信息,优选得到的工艺稳定可行,重复性好,可用于工业化生产。

OBJECTIVE To provide a reference for the industrial production of the extraction process of Compound Biqing granules by exploring the optional extraction process parameters based on determing the index weight. METHODS With the extraction capacity of diosgenin, colchicine, quercetin and ratio of extraction as comprehensive evaluation indexes, the weighting coefficient in four synthetic evaluation indexes was determined by analytic hierarchy process(AHP), criteria importance through intercriteria correlation(CRITIC) method, and mixed weighted AHP-CRITIC. And ethanol-extracting process was optimized by orthogonal test. RESULTS Mixed weighted AHP-CRITIC was more scientific, reasonable, and stable than AHP and CRITIC. The optimal process parameters were confirmed to be decocting for twice with 1.0 h in each by eight times the amount of 70% ethanol, according to the weight coefficient determined by comprehensive evaluation. CONCLUSION The weight coefficient determined by mixed weighted AHP-CRITIC is objective, real and can reflect the compound compatibility information. The optimized technology is stable, feasible, and suitable for standardized production of Compound Biqing granules.