转录激活因子3、细胞周期素D1、增殖细胞核抗原在尖锐湿疣中的表达及其意义

Expression of Stat3,Cyclin D1,PCNA in Condyloma Acuminatum

目的转录激活因子3、细胞周期素D1、增殖细胞核抗原在尖锐湿疣中的表达及其意义。方法采用免疫组化方法检测了40例尖锐湿疣(CA)组织及25例正常包皮组织中转录激活因子3(Stat 3)、细胞周期素D1(Cyclin D1)、增殖性细胞核抗原(proliferating cell nuclear antigen,PCNA)的表达。结果 Stat 3试验组阳性35例,阳性率87.5%,对照组显色10例25.0%,χ2=17.23,P<0.05。Cyclin D1试验组阳性34例,阳性率85.0%,对照组阳性9例,为36.0%,χ2=21.01,P<0.05。PCNA阳性35例,阳性率87.5%,对照组阳性14例,56.0%,χ2=11.67,P<0.05。阳性表达率差异均有统计学意义。结论转录激活因子3、细胞周期素D1、增殖细胞核抗原可能促进人乳头瘤病毒(HPV)感染细胞的增殖参与尖锐湿疣其发病机制。

Objective To express of activator of transcription 3,cyclin D1,proliferating cell nuclear antigen in genital warts and its significance. Methods Immunohistochemical method was used to detect the expression of 40 cases of condyloma acuminatum (CA) tissues, 25 cases of Stat 3 in normal prepuce tissues of cyclin D1 and PCNA. Results Stat 3 in experimental group was posi-tive in 35 cases, the positive rate was 87.5%, control group was 25% in 10 cases, χ2=17.23,P<0.05. Cyclin D1 in experimental roup was positive in 34 cases, the positive rate was 85%, control group was positive in 9 cases, the positive rate was 36%, χ2=21.01,P<0.05. 35 cases were PCNA positive, the positive rate was 87.5%, control group was positive in 14 cases, the positive rate was 56%,χ2=11.67,P<0.05. There was a statistics significance in the positive expression rate. Conclusion Activator of transcription 3, cyclin D1, proliferating cell nuclear antigen may contribute to human papillomavirus (HPV) infection of cell proliferation and involve in the pathogenesis of genital warts.