期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

东莞汉族人PCSK9基因SNP与冠心病及其预后关系研究 被引量：2

下载PDF
导出
摘要 取所有纳入研究者的外周静脉血,离心,取血细胞500μL、血清1000μL,-80℃低温保存。检测两组血脂水平相关指标。观察组和对照组在TC、LDL-C、HDL-C水平方面,差异具有统计学意义(P<0.05)。观察组患者AA同AG基因型之间TG、TC差异无统计学意义(P>0.05),LDL-C、HDL-C水平方面,差异具有统计学意义(P<0.05)。东莞汉族人PCSK9基因SNP与冠心病及其预后有相关性,临床可通过其血脂水平变化进行病症预测和疗效评价。
作者 莫玉前 钟孟如 郭志勤
机构地区 东莞市人民医院检验科
出处 《现代诊断与治疗》 CAS 2014年第8期1883-1884,共2页 Modern Diagnosis and Treatment
关键词 PCSK9基因 SNP 冠心病
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献9

二级参考文献66

  • 1赵水平,肖志杰,李全忠,聂赛,谭利民,蒋波,吴军.ATP结合盒转运子A1基因R219K变异对血脂的影响[J].中华医学杂志,2004,84(17):1421-1425. 被引量：11
  • 2刘凌,郭志刚,王琦光,刘胜林,赖文岩,屠燕.ABCA1基因启动子区-191G/C单核苷酸多态性在冠心病中的意义[J].第一军医大学学报,2005,25(6):660-662. 被引量：6
  • 3孙屏,薄小萍,郭冬平,李晓宇,胡志斌,王君,李肖蓉,范乐明,陈琪.ABCA1基因多态性与冠心病易感性的关联研究[J].中华心血管病杂志,2005,33(7):627-630. 被引量：22
  • 4刘胜林,郭志刚,刘凌,李欣,赖文岩,屠燕.124例冠心病患者三磷酸腺苷结合盒转运体A1基因启动子区-477CT单核苷酸多态性分析[J].中国动脉硬化杂志,2005,13(4):475-478. 被引量：3
  • 5Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin [J]. Circulation, 1999, 100(25):2473-2476.
  • 6Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages [ J ]. Circulation, 2001, 103 (8) : 1057 - 1063.
  • 7Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis [J]. J Biol Chem, 2002, 277(40) :37487 -37491.
  • 8Francke S, Manraj M, Lacquemant C, et al. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on3q27[J]. Hum Mol Genet, 2001, 10(24) :2751 - 2765.
  • 9Vionnet N, Hani EH, Dupont S, et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome lq21-q24[J]. Am J Hum Genet, 2000, 67(6) :1470 - 1480.
  • 10Hoefle G, Muendlein A, Saely CH, et al. The -11377 C > G promoter variant of the adiponectin gene, prevalence of coronary atheroselerosis, and incidence of vascular events in men [ J ]. Thromb Haemost, 2007, 97 (3) :451 - 457. [ 7 ] Gable DR, Matin J, Whittall R, et al. Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects[ J]. Ann Hum Genet, 2007, 71(Pt 4) :453 -466.

共引文献34

同被引文献26

  • 1吴娜琼.2011美国国家脂质协会成人家族性高胆固醇血症患者管理建议解读[J].中国医学前沿杂志（电子版）,2012,4(2):48-54. 被引量：4
  • 2lim~ni A, Harira Y,Trabelsi I, et al. Effect of E670G poly- morphism in PCSK9 gene on the risk and severity of coro- nary heart disease and ischemic stroke in a Tunisian co- hort [J]. J nol Neurosci,2014,53(2): 150-157.
  • 3Tarasov K,Ekroos K, Suoniemi M,et al. Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9deficiency [J]. J Clin Endocrinol Metab, 2014,99 ( 1 ) : E45-52.
  • 4Dandona S, Roberts R. The role of genetic risk factors in coronary artery disease [J]. Curr Cardiol Rep,2014,16(5): 479.
  • 5Saade S,Cazier JB,Ghassibe-Sabbagh M,et al. Large scale association analysis identifies three susceptibility loci for coronary artery disease [J]. PLoS One,2011,6(12) : e29427.
  • 6Werner C, Hoffmann MM,Winkler K, et al. Risk predic- tion with proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment [J]. Vascul Pharmacol, 2014 , 62(2) : 94- 102.
  • 7Jelassi A, Najah M, Slimani A, et al. Autosomal dominant hypercholesterolemia:needs for early diagnosis and cas-cade screening in the tunisian population [J]. Curt Ge- nomics, 2013,14 ( 1 ) : 25-32.
  • 8Hsu LA,Teng MS,Ko YL,et al. The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan [J]. Clin Chem Lab Med, 2009, 47(2) : 154-158.
  • 9Brouwers MC,Konrad RJ,van Himbergen TM,et al. Plas- ma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia [J]. Nutr Metab Cardiovasc Dis. 2013 Nov; 23(11) : 1115-1121.
  • 10Desai NR,Giugliano RP,Zhou J,et al. AMG 145,a mon- oclonal antibody against PCSK9,facilitates achievement of national cholesterol education program-aduh treatment panel 11I low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal an- tibody inhibition combined with statin thErapy-thrombol- ysis in myocardial infarction 57) [J]. J Am Coil Cardiol, 2014.63 (5) : 430-433.

引证文献2

二级引证文献10

现代诊断与治疗
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部