胃液培养检查在早产儿早期细菌感染诊断中应用研究

Clinical Application of Examination of Gastric Cultivation in the Early Diagnosis of Preterm Bacterial Infection

目的分析胃液培养检查在早产儿早期细菌感染诊断中应用的临床结果,探讨早产儿早期细菌感染的有效诊断措施。方法选择同期具有围生期感染高危因素早产儿65例,均在出生1h内开奶前行胃液培养检查并记录结果,结合上述早产儿临床体征与其他实验室检查结果分为感染组(n=32例)和未感染组(n=33例),比较并分析两组早产儿胃液培养检查情况。结果两组早产儿胃液培养阳性率比较,差异具有高度统计学意义(P<0.01),感染组显著高于未感染组;胃液培养具有较高的特异性、敏感性、阳性预测值与阴性预测值。感染菌株以革兰氏阴性杆菌为主,其次为革兰氏阳性球菌。结论对早产儿应积极进行胃液培养检查,这对早产儿早期细菌感染诊断具有重要的临床意义。

Objective To analyze the clinical result of gastric juice cultivation in the early diagno-sis of preterm bacterial infection and explore effective diagnostic measures. Methods 65 preterm with risk perinatal factors of infection in the same period were collected, they were given the gas-tric juice cultivation checking and written the results in 1 hour after birth before drinking milk. According to the clinical symptoms and other laboratory test results, they were divided into the infected group (n=32 cases) and non-infected group (n=33 patients). Gastric cultivation inspection was compared and analyzed in two groups. Results The difference was highly statistically signifi-cant (P<0.01) in the positive rate of gastric cultivation, and it was significantly higher than that in non-infected group. Gastric cultivation was with a high specificity, sensitivity, positive predictive value and negative predictive value. Infection was mainly with Gram-negative bacteria, followed by Gram-positive cocci.Conclusion Preterm children should be actively given the gastric cultivation examination, which has an important clinical significance in the early diagnosis of premature bac-terial infections.