孕中期唐氏筛查在产前诊断中的临床应用

Clinical Applications of Second Trimester Screening for Down in Prenatal Diagnosis

目的：分析孕中期唐氏筛查在产前诊断中的临床应用价值。方法选取2012年4月～2013年4月本院108例孕中期妊娠妇女利用唐氏筛查行产前诊断的临床资料进行回顾性分析，按照患者的筛查结果情况分为两组，43例高风险孕妇作为研究组，65例低风险孕妇作为对照组，分析两组患者的筛查结果与妊娠结局情况。结果研究组出现不良妊娠结局率为41.86%（18/43），高于对照组的9.23%（6/65），比较差异明显（P＜0.05）；研究组不良妊娠结局产妇AFP MOM值明显低于正常妊娠者，β-HCG MOM值明显高于正常妊娠者，比较差异明显（P＜0.05）。结论孕中期唐氏筛查在产前诊断中的临床应用价值显著，为产妇提供胎儿生长发育情况的初步诊断依据。

Objective To study the clinical applications of second trimester screening for Down in prenatal diagnosis. Methods Clinical data of 108 pregnant women who were in the second trimester of pregnancy (15~21 weeks) in our hospital from April 2012 to April 2014, using prena-tal screening for Down, were retrospectively analyzed. They were divided into two groups on screening results. 43 cases of high-risk pregnant women were treated in research group, 65 cases of low-risk pregnant women were treated in control group to analyze the results of the two groups of patients screened with pregnancy outcome situation. Results Adverse pregnancy outcome in re-search group was 41.86% (18/43), higher than 9.23% (6/65) in control group, the difference was significant(P<0.05); The value of MOM in pregnancy with abnormal outcome in experimental group was higher than that in control group, and the difference was significant(P<0.05). The value of β￣HCG and MOM was significant higher than normal pregnant women(P<0.05). Conclusions Clinical value of second trimester screening for Down in prenatal diagnosis is significant to provide pre-liminary diagnosis of the growth and development of fetal.