纳洛酮联合醒脑静用于颅脑外伤患者神经功能改善的疗效分析

Efficacy Analysis of Naloxone Combined with Xingnaojing Injection for Neurological Improvement of Traumatic Brain Injury Patients

目的：探究纳洛酮联合醒脑静用于颅脑外伤患者对于神经功能的改善和对疗效的影响。方法研究对象选取2006年5月～2013年5月我院收治的70例颅脑外伤患者，根据用药方案不同分为观察组和对照组各35例，对照组单纯应用纳洛酮治疗，观察组则应用纳洛酮联合醒脑静进行治疗，两组患者的治疗时间均为20d，治疗结束后对两组患者的疗效进行判定对比，并对治疗前、治疗10d、治疗20d两组患者的神经功能缺损评分进行统计对比。结果观察组患者的总有效率为82.86%（29/35），显著高于对照组的65.71%（23/35），差异具有统计学意义（P＜0.05）；治疗前两组患者的NDS评分对比无显著差异，治疗10、20d时观察组患者的NDS评分显著低于对照组，差异具有统计学意义（P＜0.05）。结论纳洛酮联合醒脑静治疗颅脑外伤患者的疗效确切，相较于单纯应用纳洛酮治疗能够有效的提高疗效，改善患者的神经功能缺损状况，值得在临床上推广和应用。

Objective To explore the effect of naloxone combined with Xingnaojing injection for neurological improvement of traumatic brain injury patients. Methods 70 patients with craniocere-bral trauma were selected from May 2006 to May 2013 in our hospital, according to the different regimens, they were divided into the observation group and the control group, 35 cases in each group. The control group was given naloxone therapy, observation group was given naloxone com-bined with Xingnaojing. Treatment time of two groups was 20 days. After treatment, efficacy of two groups were judged and compared, and neurological deficit of two groups were statistically compared before treatment, 10, 20d after the treatment. Results Total effective rate of observation group was 82.86% (29/35), significantly higher than the control group of 65.71% (23/35). The dif-ference was statistically significant (P<0.05); There were no significant difference in neurological deficits score (NDS) of two groups before the treatment. NDS in observation group was significant-ly lower than control group in 10, 20d afrer the treatment, the difference was statistically signifi-cant(P<0.05). Conclusion The efficacy of naloxone combined with Xingnaojing in the treatment of craniocerebral trauma is exact. Compared with the simple application of naloxone therapy, it can improve the curative effect effectively and improve nervous function defect of patients, is worthy of clinical popularization and application.