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CXCR7在乳腺癌新辅助化疗诊治及预后中的临床研究

Clinical Research of CXCR7 in Diagnosis and Prognosis of Neoadjuvant Chemotherapy in Breast Cancer
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摘要 目的研究CXCR7作为一种新的检测指标在乳腺癌的治疗效果及预后判断中的作用。方法应用RT-PCR方法检测乳腺癌癌组织CXCR7基因在新辅助化疗前的表达情况。结果乳腺癌组织中CXCR7表达水平明显高于正常乳腺组织,差异具有统计学意义(P<0.05);尽管正常细胞表面很少表达CXCR7分子,但是其细胞内也会表达CXCR7m RNA。CXCR7m RNA在癌组织中的表达量明显高于正常组织,甚至超过20倍,经新辅助化疗后肿块缩小程度与CXCR7表达量呈负相关,即肿块缩小程度越高,预后质量越高,CXCR7表达量越低。结论 CXCR7与乳腺癌的发生、发展及预后有一定的相关性,可能是新辅助化疗的疗效评价指标之一。
作者 陈军 曹亚丽 吴晓波 刘秋明 欧阳倩雯 胡平华
机构地区 南昌市第三医院
出处 《现代诊断与治疗》 CAS 2014年第19期4348-4349,共2页 Modern Diagnosis and Treatment
关键词 CXCR7 RT-PCR 乳腺癌
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献25

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现代诊断与治疗
2014年 第19期

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