体内铁负荷在冠心病发病中的机制

Association between I ron Overload and the Pathogenesis of Coronary Atheroscl-erotic Heart Disease

已有研究表明,体内铁负荷与冠心病的发生显著相关,可以影响冠心病的严重程度及预后。但迄今为止,铁负荷在冠心病发病中的确切机制尚不完全明确,认为主要与氧化应激、缺血再灌注、血管内皮损伤、炎症反应等有关。

Studies have shown that iron overload has significant correlation with coronary atherosclerotic heart disease.It may influence the severity and prognosis of coronary atherosclerotic heart disease. However,the exact pathogenesis of iron overload in coronary atherosclerotic heart disease are unclear.It is widely regarded that it was associated with the oxidative stress,ischemia-reperfusion,damage of vascular endothelial cell,inflammatory reaction and so on.