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胸腔内注射丝裂霉素联合培美曲塞与顺铂静脉化疗治疗19例恶性胸膜间皮瘤临床疗效观察

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摘要 回顾性分析19例经胸腔镜确诊恶性胸膜间皮瘤患者,使用培美曲塞与顺铂静脉化疗,并行胸腔内注射丝裂霉素.结果19例患者中,17例(89.47%)胸腔积液得到控制,13例(68.42%)胸腔积液癌细胞检查由阳性转为阴性;获CR 4例,PR 10例,SD 3例,PD 2例;总有效率为73.68%,疾病控制率为89.47%,肿瘤进展时间为7.2个月,中位生存期为12.1个月,1年生存率为42.10%.主要不良反应为胃肠道反应、中性粒细胞减少等,多为1~2级,对症处理后均可恢复.胸腔内注射丝裂霉素联合全身化疗治疗恶性胸膜间皮瘤疗效较好,不良反应轻,值得临床推广应用.
出处 《现代诊断与治疗》 CAS 2014年第19期4439-4441,共3页 Modern Diagnosis and Treatment
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