成人隐匿性自身免疫糖尿病与甲状腺自身免疫的关系

Relationship between Adult-onset Latent Autoimmune Diabetes and Thyroid Autoimmunity

目的对成人隐匿性自身免疫糖尿病(LADA)与甲状腺自身免疫之间的关系进行探讨。方法选取在我院就诊的300例糖尿病患者,其中包括94例LADA患者,100例1型糖尿病(T1DM)患者,106例2型糖尿病(T2DM)患者,并与100例健康人群相对照,对健康人群与患病人群均进行甲状腺球蛋白抗体(TG-Ab)及甲状腺过氧化物酶抗体检测(TPO-Ab)检测,糖尿病患者还需进行谷氨酸脱羧酶检测(GAD-Ab),比较检查结果的差异性。结果 (1)LADA组的阳性检出率均较正常对照组高(P<0.05),同时与T2DM组相比,LADA组与T1DM组的TPO-Ab检出率更高(P<0.05),而LADA组与T1DM组的检出率之间无显著性差异(P>0.05)。(2)对于LADA患者,甲状腺抗体检测阳性的患者其甲状腺功能异常发生率高于抗体检测阴性者,两组之间无显著性差异(P>0.05)。结论通过甲状腺抗体检测,发现LADA患者的甲状腺功能异常的发生风险较大,其十分容易合并自身的甲状腺免疫紊乱。

Objective To discusses the relationship between adult-onset latent autoimmune dia-betes (LADA)and thyroid autoimmunity. Methods 300 cases of diabetic patients including 94 cases of LADA patients, 100 T1DM patients, 106 T2DM patients, were compared with 100 cases of healthy people. They are detected thyroglobulin antibody (TG￣Ab) and thyroid peroxidase anti-body detection (TPO￣Ab), at the same time patients with diabetes accepted glutamic acid decar-boxylase (GAD￣Ab) detection, compared the differences of test. Results (1)The positive detection rate of LADA group was higher than normal control group (P<0.05), compared with T2DM group, the T1DM group of TPO￣Ab detection rate was higher (P<0.05), while, the detection rate in the T1DM group and LADA group was no significant difference (P>0.05). (2)For LADA patients, ab-normal thyroid function rate in patients with thyroid antibody detection positive rate was higher than the negative antibody detection, there was no significant difference between two groups (P>0.05).Conclusion By thyroid antibody detection, the risk of thyroid dysfunction in patients is big-ger, it''s easy to merge their own immune thyroid disorders.