冠心病患者HCY、Hs-CRP、LP(a)和DD的表达及其在病程监测中的临床应用

Clinical Applications Analysis of HCY,Hs-CRP,LP(a) and DD Combined on Monitoring Coronary Heart Disease

目的探讨HCY、Hs-CRP、LP(a)和DD联合在冠心病病程监测中的临床应用价值。方法选取不同类型冠心病患者200例作为观察组,依据病情分为急性心肌梗死(AMI组,48例)、稳定型心绞痛(SAP组,52例)、不稳定型心绞痛(UAP组,53例)以及无症状性心肌缺血(SMI组,47例)。并选同期体检正常成年人200例作为对照组。对各组HCY、Hs-CRP、LP(a)和DD水平及各指标的阳性率进行比较。结果观察组HCY、Hs-CRP、LP(a)和DD水平均显著性高于对照组,差异有统计学意义(P<0.05);AMI组、SAP组和UAP组HCY、Hs-CRP、LP(a)和DD水平均显著高于SMI组,差异有统计学意义(P<0.05);AMI组和UAP组HCY、Hs-CRP、LP(a)和DD水平均显著高于SAP组,差异有统计学意义(P<0.05);冠心病各组中四指标联合检测阳性率均显著性低于各指标单独应用,差异有统计学意义(P<0.05)。结论 HCY、Hs-CRP、LP(a)和DD水平可有效反映冠心病患者病情程度,四项指标联合监测能更准确的对患者病情进行反映。

Objective To investigate the clinical value of HCY, Hs-CRP, LP(a) and DD combined on monitoring coronary heart disease. Methods 200 patients with different types of coronary heart disease were selected as observation group, and were divided into acute myocardial infarction(AMI group,48 cases), stable angina pectoris(SAP group,52 cases), unstable angina pectoris(UAP group,53 cases), and silent myocardial ischemia(SMI group,47 cases) according to the patient's condition. And 200 cases of normal adult physical examination people in the same period were selected as control group. HCY, Hs-CRP, LP(a) and DD levels of each group and various indicator positive rates were compared. Results HCY,Hs-CRP, LP(a) and DD levels of observation group were significantly higher than control grous,the difference was statistically significant(P<0.05);HCY, Hs-CRP,LP(a) and DD levels of AMI group, SAP and UAP group were significantly higher than SMI group, the difference was statistically significant(P<0.05);HCY, Hs-CRP,LP(a) and DD levels of AMI and UAP groups were significantly higher than the SAP group, the difference was statistically significant(P<0.05); The positive rates of four indicator combined in each coronary heart disease group were significantly lower than alone indicators, the difference was statistically significant(P<0.05). Conclusion HCY, Hs-CRP, LP(a) and DD levels can effectively reflect the severity of coronary heart disease, and four indicator combined can accurately reflect patient condition.