摘要
目的观察新癀片对急性痛风性关节炎患者血清白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)的影响。方法选择急性痛风性关节炎患者92例,随机分为新癀片治疗组和双氯芬酸钠喷雾剂治疗对照组。于治疗前、治疗3d、治疗7d后分别检测血清IL-1β和TNF-α含量。结果观察组于新癀片治疗3d后血清IL-1β和TNF-α水平即明显降低(P<0.01),以后继续下降,与对照组比较差异有统计学意义(P<0.05)。结论新癀片可降低急性痛风性关节炎患者血清IL-1β和TNF-α的水平,达到快速控制炎性反应的目的,可能是其治疗急性痛风性关节炎的机制之一。
Objective To observe the effects of Xinhuang tablets on interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in serum of patients with acute gouty arthritis.Methods 92 patients with acute gouty arthritis were randomly divided into Xinhuang tablets treatment group(46 cases)and diclofenac sodium spray treatment group(46 cases).The changes of IL-1β and TNF-αin serum of patients were observed before and after treatment. Results After treatment, the average serum levels of IL-1β and TNF-αin Xinhuang tablets treatment group were descended significantly,and there were significant differences found between these 2 patient groups. Conclusion Xinhuang tablets may cure the disease and reduce the levels of IL-1β and TNF-αin patients with acute gouty arthritis, which might be looked as immune suppression effects.
出处
《现代诊断与治疗》
CAS
2014年第24期5531-5533,共3页
Modern Diagnosis and Treatment
关键词
新癀片
急性痛风性关节炎
IL-1Β
TNF-Α
Xinhuang tablets
Acute gouty arthritis
Interleukin-1β
Tumor necrosis factor-α
