脑胶质瘤血流容积与肿瘤微血管密度的相关性研究

Relationship between Cerebral Blood Volume and Tumor Micro-vessel Density in Glioma

目的 运用磁共振灌注成像 (PWI) ,探讨肿瘤血流容积 (rCBV)与微血管密度 (MVD)的相关性。资料与方法 30例星形细胞瘤 (AS) ,其中低分级 (Ⅰ～Ⅱ级 ) 12例 ,高分级 (Ⅲ～Ⅳ级 ) 18例。常规MRI扫描后 ,行PWI扫描 ,计算肿瘤rCBV值及其与正常脑白质的比值 ,并用免疫组织化学技术测量MVD ,观察PWI结果与病理分级和MVD的相关性。结果 低分级ASrCBV值为 4 1.5 4± 2 5 .16 ,rCBV比值为 2 .83± 1.12 ,MVD为 37.2 4± 2 5 .78;高分级ASrCBV值为 14 2 .0 0± 82 .75 ,rCBV比值为 9.0 4± 2 .36 ,MVD为 73.6 7± 19.85。两组rCBV值、rCBV比值均有显著统计学差异 (P <0 .0 0 1) ,rCBV和MVD密切相关 (r=0 .86 ,P <0 .0 0 1)。结论 不同分级的胶质瘤rCBV差别显著 。

Objective To discuss the correlation between cerebral blood volume (rCBV) and tumor micro-vessel density (MVD) in glioma by using MR perfusion-weighted imaging (PWI).Materials and Methods MR PWI was performed in 30 patients with glioma, including 12 cases of low-grade (grade Ⅰ～Ⅱ) and 18 cases with high-grade (grade Ⅲ～Ⅳ). PWI was subsequently carried out after routine MRI scanning. The perfusion data were deconvoluted to calculate the rCBV values of both the lesion and the normal white matter, and the ratio of the lesion to white matter. MVD was measured with immunohistochemical method. The correlation of PWI results with the pathologic grade and MVD was analyzed.Results The rCBV, rCBV ratio and MVD were 41.54±25.16, 2.83±1.12 and 37.24±25.78 in low-grade group, while 142.00±82.75, 9.04±2.36 and 73.67±19.85 in high-grade group, respectively. Statistically significant difference in rCBV, rCBV ratio existed between low-grade group and high-grade group (P<0.001). The rCBV was closely correlated with MVD (r=0.86, P<0.001).Conclusion Significant difference in rCBV exists between gliomas of different grade. The rCBV of the tumor correlates well with MVD.