血栓闭塞性脉管炎的免疫相关性研究进展

The progress of study in thromboangiitis obliterans with inflammation and immunity

血栓闭塞性脉管炎(TAO)是一种非动脉粥样硬化性、节段闭塞性、血管炎性病变,主要累及四肢中小血管,好发于吸烟的青壮年男性。TAO与吸烟、感染、遗传、性激素、炎症免疫、环境等多种因素具有相关性,但其病因及发病机制尚不明确。近年来的研究发现炎症免疫与疾病的发生密切相关,炎症免疫在疾病的发病过程中可能起着重要作用,但其作用机制尚不清楚。

Thromboangiitis obliterans(TAO)is a nonatherosclerotic,segmental occlusive,inflammatory vascular disease that mainly affects the small-and medium-size arteries and veins in the upper and lower extremities,frequently occurs in young and middle-aged males smokers.Thromboangiitis obliterans is associated with tobacco,infection,gene,sex hormone,inflammation,immunity,environment,etc.But the etiology and pathogenesis of thromboangiitis obliterans are still unclear.Recent studies have found that inflammation and immunity are closely related to thromboangiitis obliterans.Inflammation and immunity may play an important role in the pathogenesis of the disease.But the mechanism is still unknown.