晚期肿瘤维持治疗疗效评判的研究进展

Research Progress on Efficacy Evaluation in Maintenance Treatment for Advanced Cancer Patients

晚期肿瘤维持治疗即一线治疗得到临床获益病情稳定后,继续采用药物治疗达到改善生活质量、延缓肿瘤进展、提高存活率的目的。维持治疗的停药指征为疾病进展或出现不可耐受的不良反应。及时调整二线治疗方案以延长患者生存期的方式已经得到认可。因此,临床上迫切需要一种判断维持治疗疗效、确定更换二线治疗时机的预测指征。全文就影像学、肿瘤标志物、临床表现和分子检测等常见的疗效评价手段作一综述。

When the clinical benefit and stable condition are achieved for patients with advanced cancer,the purpose of maintenance treatment is to improve the quantity of life,to delay tumor progression,and to prolong the survival of patients. The terminal point of maintenance treatment is the progression of disease or intolerable adverse effects. It has been generally recognized that to early discover the progression and to adjust second-line therapeutic protocol can prolong the survival. So it is necessary to have indicators for evaluating the efficacy of maintenance treatment and the time of scheduling second-line chemotherapy. In this review,the commonly used evaluation means are discussed,including imaging,tumor markers,molecular detection and clinical features.