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LncRNA PVT1与恶性肿瘤治疗的研究进展 被引量：5

Research Progress of LncRNA PVT1 in Cancer Therapy
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摘要 长链非编码RNA-PVT1(lncRNA PVT1)作为一种重要的致癌性非编码RNA在多种恶性肿瘤呈现高表达并提示不良预后,其通过影响肿瘤细胞的增殖、迁移、侵袭和凋亡促进肿瘤的发生发展。目前大量的研究表明lncRNA PVT1在多种肿瘤中具有致癌活性或驱动作用,比如以竞争性内源RNA或作为"分子海绵"负性调控肿瘤相关miRNA的表达促进肿瘤发生等,因此,基于lncRNA PVT1在肿瘤发病中的关键作用,进一步的深入研究有望为恶性肿瘤提供新的治疗靶点。 LncRNA PVT1 is an important carcinogenic long non-coding RNA,and the high expression of lncRNA PVT1 in malignant tumors suggests a poor prognosis. LncRNA PVT1 can promote the tumorigenesis and development of cancers by affecting cell proliferation,migration,invasion and apoptosis. Accumulating evidence has indicated that lncRNA PVT1,as a competing endogenous RNA or a molecular sponge,negatively modulates miRNA expression to promote the cancer development. Based on the critical role of lncRNA PVT1 in the pathogenesis of cancers,further study would provide a novel therapeutic target for various cancers in the future.
作者 潘雪峰 高春芳 PAN Xue-feng;GAO Chun-fang(PLA 150 Central Hospital,Luoyang 471031,China;The Second Military Medical University, Shanghai 200433,China)
机构地区 解放军第 解放军第二军医大学
出处 《肿瘤学杂志》 CAS 2019年第2期145-151,共7页 Journal of Chinese Oncology
关键词 长链非编码RNA PVT1 肿瘤 治疗靶点 ,long non-coding RNA plasmacytoma variant translocation 1 neoplasm therapeutic target
分类号 R730.5 [医药卫生—肿瘤]
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  • 1Ahmadiyeh, N., Pomerantz, M.M., Grisanzio, C., Herman, P., Jia, L., Alrnendro, v., He, H.H., Brown, M., Liu, X.S., Davis, M., Caswell, J.L., Beckwith, C.A., Hills, A., Macconaill, L., Coetzee, G.A., Regan, M.M., Freedman, M.L., 2010. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc. Nat!. Acad. Sci. USA 107,9742-9746.
  • 2Beck-Engeser, G.B., Lum, A.M., Huppi, K, Caplen, N.J., Wang, B.B., Wabl, M., 2008. Pvtl-encoded microRNAs in oncogenesis. Retrovirology 5,4.
  • 3Boehm, T., Rabbitts, T.H., 1989. The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors. FASEB J. 3, 2344-2359.
  • 4Broeks, A., Schmidt, M.K, Sherman, M.E., Couch, FJ., Hopper, J.L., Dite, G.S., Apicella, c., Smith, L.D., Hammet, F, Southey, M.C., Van 't Veer, L.J., de Groot, R., Srnit, V.T., Fasching, P.A., Beckmann, M.W., Jud, S., Ekici, AB., Hartmann, A, Hein, A, Schulz-Wendtland, R., Burwinkel, B., Marrne, F, Schneeweiss, A., Sinn, H.P., Sohn, C., Tchatchou, S., Bojesen, S.E., Nordestgaard, B.G., Flyger, H., Orsted, D.D., Kaur-Knudsen, D., Milne, R.L., Perez, J.r., Zamora, P., Rodriguez, P.M., Benitez, J., Brauch, H., Justenhoven, c., Ko, Y.D., Hamann, U., Fischer, H.P., Bruning, T., Pesch, B., Chang-Claude, J., Wang-Gohrke, S., Bremer, M., Karstens, J.H., Hillernanns, P., Dork, T., Nevanlinna, H.A, Heikkinen, T., Heikkila, P., Blomqvist, C., Aittomaki, K, Aaltonen, K, Lindblom, A, Margolin, S., Mannermaa, A, Kosma, V.M., Kauppinen, J.M., Kataja, v.. Auvinen, P., Eskelinen, M., Soini, Y., Chenevix-Trench, G., Spurdle, AB., Beesley, J., Chen, X., Holland, H., Lambrechts, D., Claes, B., Vandorpe, T., Neven, P., Wildiers,Henderson, B.E., Le Marchand, L., Kolonel, L.N., Alnaes, G.G., Kristensen, v., Borresen-Dale, A.L., Hunter, DJ., Hankinson, S.E., Andrulis, 1.L., Mulligan, A.M., O'Malley, F.P., Devilee, P., Huijts, P.E., Tollenaar, R.A, Van Asperen, C.1., Seynaeve, C.S., Chanock, S.J., Lissowska, J., Brinton, L., Peplonska, B., Figueroa, J., Yang, X.R., Hooning, M.J., Hollestelle, A., Oldenburg, R.A, Jager, A, Kriege, M., Ozturk, B., van Leenders, G.J., Hall, P., Czene, K, Humphreys, K, Liu, J., Cox, A., Connley, D., Cramp, H.E., Cross, S.S., Balasubramanian, S.P., Reed, M.W., Dunning, AM., Easton, D.F., Humphreys, M.K, Caldas, C., Blows, F., Driver, K, Provenzano, E., Lubinski, J., Jakubowska, A, Huzarski, 1., Byrski, 1., Cybulski, c., Gorski, B., Gronwald, J., Brennan, P., Sangrajrang, S., Gaborieau, v., Shen, CY, Hsiung, C.N., Yu, J.C., Chen, S.T., Hsu, G.C., Hou, M.F., Huang, C.S., Anton-Culver, H., Ziogas, A., Pharoah, P.D., Garcia-Closas, M., 2011. Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum. Mol. Genet. 20, 3289-3303.
  • 5Carramusa, L., Contino, F., Ferro, A., Minafra, L., Perconti, G., Giallongo, A, Feo, S., 2007. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells. J. Cell. Physiol. 213, 511-518.
  • 6Chan, M., Ji, S.M., Liaw, C.S., Yap, Y.S., Law, H.Y., Yoon, C.S., Wong, c.v, Yong, WS., Wong, N.S., Ng, R., Ong, KW, Madhukumar, P., Oey, C.L., Tan, P.H., Li, H.H., Ang, P., Ho, G.H., Lee, A.S., 2012. Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. Breast Cancer Res. Treat. 136, 209-220.
  • 7Dworkin, A.M., Ridd, K, Bautista, D., Allain, D.C., lwenofu, O.H., Roy, R., Bastian, B.C., Toland, AE., 2010. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genet. 6, e1001136.
  • 8Easton, D.F., Pooley, KA, Dunning, AM., Pharoah, P.D., Thompson, D., Ballinger, D.G., Struewing, J.P., Morrison, J., Field, H., Luben, R., Wareham, N., Ahmed, S., Healey, C.S., Bowman, R., Meyer, KB., Haiman, C.A, Kolonel, L.K, Henderson, B.E., Le Marchand, L., Brennan, P., Sangrajrang, S., Gaborieau, v., Odefrey, F., Shen, c.Y., Wu, P.E., Wang, H.C., Eccles, D., Evans, D.G., Peto, J., Fletcher, 0., Johnson, N., Seal, S., Stratton, M.R., Rahman, N., Chenevix-Trench, G., Bojesen, S.E., Nordestgaard, B.G., Axelsson, C.K, Garcia-Closas, M., Brinton, L., Chanock, S., Lissowska, J., Peplonska, B., Nevanlinna, H., Fagerholm, R., Eerola, H., Kang, D., Yoo, KY., Noh, D.Y., Ahn, S.H., Hunter, D.J., Hankinson, S.E., Cox, D.G., Hall, P., Wedren, S., Liu, J., Low, Y.L., Bogdanova, N., Schurmann, P., Dork, T., Tollenaar, R.A., Jacobi, C.E., Devilee, P., Klijn, J.G., Sigurdson, AJ., Doody, M.M., Alexander, B.H., Zhang, J., Cox, A, Brock, I.W, MacPherson, G., Reed, M.W., Couch, F.J., Goode, E.L., Olson, J.E., Meijers-Heijbo.
  • 9Feo, S., Di Liegro, c., Jones, 1., Read, M., Fried, M., 1994. The DNA region around the c-myc gene and its amplification in human tumour cell lines. Oncogene 9, 955-961.
  • 10Fletcher, 0., Johnson, N., Gibson, L., Coupland, B., Fraser, A, Leonard, A., dos Santos Silva, 1., Ashworth, A, Houlston, R., Peto, J., 2008. Association of genetic variants at 8q24 with breast cancer risk. Cancer Epidemiol. Biomarkers Prevo 17,702-705.

共引文献11

同被引文献31

引证文献5

二级引证文献9

肿瘤学杂志
2019年 第2期

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