肿瘤疫苗临床研究评价及进展

Progress on Clinical Application of Cancer Vaccines

肿瘤疫苗是近年来肿瘤疾病的新兴治疗手段之一,其种类繁多,疗效显著,有着良好的应用前景。肿瘤疫苗可分为全细胞疫苗、多肽疫苗、基因工程疫苗和单克隆抗体疫苗等类别。2011～2017年间有15个肿瘤疫苗类新药获批上市,实现了基础研发到临床应用的迈进,为肿瘤的治疗模式带来了令人振奋的变革。全文就近几年肿瘤疫苗领域的新药从分类、作用机制及临床应用进展方面作一综述。

Tumor vaccine is one of the emerging treatment methods for malignant diseases in recent years,which has a wide range of types,remarkable curative effect and good application prospect. Tumor vaccines can be classified into whole cell vaccine,polypeptide vaccine,genetic engineering vaccine and monoclonal antibody vaccine. From 2011 to 2017,15 new kinds of vaccine-type drugs were approved and marketed,bringing exciting changes in the therapeutic modality of malignant diseases. In this article,new tumor vaccines are reviewed in terms of classification,mechanism of action and clinical application.