放疗所致心脏疾病的机制及其在乳腺癌中的相关研究

Mechanisms of Radiation-induced Cardiac Disease Associated with Radiotherapy and Relative Research in Breast Cancer

乳腺癌术后放疗所致心脏疾病的风险近年来被日益重视,如何减少放疗所致远期心脏毒性成为普遍共识。全文从体外实验、动物实验和临床研究等多个角度,探讨精确放疗引起心脏疾病的放射生物学机制,尤其关注其在乳腺癌中的相关研究,上述机制研究与影像学、剂量学研究相结合,有利于进一步优化放疗计划。

The risk of heart disease in post-operative radiotherapy of breast cancer patients has been recognized recently.There is general agreement that we should reduce the late risk of radiation-induced heart disease.In this article,we discuss mechanisms of radiation-induced cardiac disease from several aspects such as vivo researches,animal experiments and clinical studies.These kinds of researches in breast cancer are paid special attentions.Results of these mechanistic studies would need to incorporate imaging and dosimetric studies in order to further optimizing the radiation treatment plan.