首都医科大学附属北京妇产医院1998～2017年卵巢癌病例特点分析

Analysis of Ovarian Cancer Cases in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from 1998 to 2017

[目的]探讨首都医科大学附属北京妇产医院近20年间收治卵巢癌病例特点的变化。[方法]收集1998年1月至2017年12月首都医科大学附属北京妇产医院收治的北京籍卵巢癌患者1075例为研究对象。采用回顾性分析法,从发病年份、年龄、组织病理学类型、手术-病理分期等分析20年间卵巢癌病例特点的变化。[结果]<40岁组患者构成比从1988~2007年的28.03%下降到2008~2017年的14.17%(P<0.05),40~60岁组及>60岁组卵巢癌构成比分别由1998~2007年的57.50%及14.47%上升到2008~2017年的66.48%及19.34%(P<0.05)。不同年份组主要病理类型是上皮性卵巢癌,且构成比从1998~2007年的72.56%上升至2008~2017年的90.80%(P<0.05)。生殖细胞肿瘤及性索-间质肿瘤构成比均有下降,分别由1998~2007年的13.56%及12.66%下降到2008~2017年的3.83%及4.79%(P<0.05)。上皮性卵巢癌在40岁及以上年龄组是主要病理类型,特别是>60岁老年患者。年轻患者病理类型构成中,上皮性卵巢癌从1998~2007年的38.71%上升至2008~2017年的68.92%(P<0.05),生殖细胞肿瘤从1998~2007年的45.80%下降至2008~2017年的20.27%(P<0.05)。年轻患者多为Ⅰ期,Ⅲ期及以上卵巢癌患者所占比例从1998~2007年的46.11%上升到2008~2017年的60.34%(P<0.05)。[结论] 20年来卵巢癌主要发病人群年龄仍以40~60岁为主。上皮性卵巢癌是主要的病理类型,特别是>60岁老年患者人群,在年轻患者中其构成比呈上升趋势。

[Objective]To analyze the characteristics of ovarian cancer cases in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from 1998 to 2017.[Methods]The clinical and pathological data of1075 patients with ovarian cancer admitted in our hospital from January 1998 to December 2017 were retrospectively analyzed.[Results]Composition ratio of patients aged<40 years was decreased from 28.03%in1998~2007 to 14.17%in 2008~2017(P<0.05),while those of patients aged 40~60 years and>60 years were increased from 57.50%and 14.47%in 1998~2007 to 66.48%and 19.34%in 2008~2017(P<0.05),respectively.The rate of epithelial ovarian cancer rose from 72.56%in 1998~2007 to 90.80%in 2008~2017(P<0.05),while those of germ cell tumor and gonadal stromal cell tumor were decreased from 13.56%and 12.66%in 1998~2007 to 3.83%and 4.79%in 2008~2017(P<0.05).Epithelial ovarian cancer was the major pathological type in patients aged above 40 years,particularly in those aged>60 year-old.The rate of epithelial ovarian cancer in young patients rose from 38.71%in 1998~2007 to 68.92%in 2008~2017(P<0.05).The ovarian cancer was mostly in stageⅠin younger patients.There was an increasing trend of stageⅢovarian cancer,which was increased from 46.11%in 1998~2007 to 60.34%in 2008~2017(P<0.05).[Conclusion]The age group 40 to 60 years is still the main risk population for ovarian cancer.Epithelial ovarian cancer is the main pathological type,especially in the patients aged over 60 years-old,and most patients are in the late stage at the diagnosis.