电焊作业工人血中几种生物指标变化的探讨

Altered trace elements,SOD,LPO-MDA,systemiciron metabolism in welders

目的 探讨电焊作业工人血中 5种微量元素、过氧化物歧化酶 (SOD)和脂质过氧化代谢产物———丙二醛 (LPO -MDA)及铁代谢蛋白的变化。方法 分别测定电焊作业工人 (锰暴露人群 )和对照人群全血SOD和血清LPO -MDA、铁、锰、铅、铜、锌及血清铁蛋白、转铁蛋白、转铁蛋白受体的浓度。结果 暴露组的SOD活性下降 ,LPO-MDA升高 ,与对照组比较有显著性差异 (P <0 0 5) ;暴露组血清转铁蛋白量比对照组高 1 19倍 ;转铁蛋白受体水平低于对照组 1 3 4倍。暴露组与对照组血清中 5种微量元素含量测定结果表明 ,暴露组锰和铁的含量均明显高于对照组 (P <0 0 1) ,而锌和铅的含量则明显低于对照组 (P <0 0 1)。结论 锰暴露导致作业工人血中的脂质过氧化(LPO -MDA)水平明显升高 ,参与铁代谢蛋白合成的血清转铁蛋白含量、转铁蛋白受体发生了变化 。

ObjectiveTo investigate the alteration of trace elements,SOD,LPO-MDA,systemic iron metabo lism,an occupational epidemiological survey was designed.MethodsTo measure serum LPO-MDA,iron,manganese,copper,le ad,zinc,ferritin,transferrin,transferrin receptors and blood SOD in both populat ion exposed to manganese and controls.Results(1)The activity of SOD decreased and the level o f LPO-MDA increased.(2)The transferrin concentrations in serum were significantl y higher(about 1.19 fold,P<0 05)in welders than in controls.In contrast,tr ansferrin receptors were significantly lower(about 1.34 fold)in welders than con trols(P<0 01).There was no difference in serum ferritin between the two gr oups(P>0 05).(3)Mn and Fe concentrations in welders were higher than those in control subjects.However,the concentrations of serum Zn and Pb were lower th an those of control subjects.ConclusionThere was the alteration of SOD and LPO-MDA in welders.There was increase of transferrin and decrease of transferrin receptors ,indicating alterations in peripheral iron metabolism in manganese-exposed worke rs.The welding fume among career welders disturbed the serum homeostasis of trac e elements.