中性粒细胞淋巴细胞比率与原发性肝癌预后的相关分析

Relationship of blood neutrophil-lymphocyte ratio with clinicopathological characteristics and prognosis in primary hepatocellular carcinoma

目的探讨中性粒细胞淋巴细胞比率与原发性肝癌患者临床病理特点及预后的关系。方法回顾性分析2000年4月至2007年12月间387例接受根治手术的原发性肝癌患者临床资料,根据中性粒细胞淋巴细胞比率(neutrophil-lymphocyte ratio,NLR)将患者分为低NLR组(NLR<2.0)和高NLR组(NLR≥2.0)。比较分析两组患者的临床病理学特点和预后。结果 NRL表达水平与肝癌患者性别、术前ALT水平、乙肝病毒抗原(HbsAg)阳性和肿瘤大体类型密切相关。低NLR组患者5年生存率明显高于高NLR组,分别为31.6%和7.3%,差异有统计学意义(P<0.05)。Cox回归分析表明NLR水平、乙肝病毒感染和ALT水平是总体患者的独立预后因素。结论对接受根治手术的原发性肝癌患者,术前NLR水平与预后负相关,术前NLR水平为其独立预后因子。

Objective To evaluate the correlation between neutrophil-lymphocyte ratio and clinicopathological characteristics and prognosis in primary hepatocellular carcinoma.Methods Clinicopathological and prognostic data of 387 patients with primary hepatocellular carcinoma undergoing radical surgery from April 2000 to December 2007 were studied retrospectively.The enrolled patients were divided into low-NLR group(NLR<2.0) and high-NLR group(NLR≥2.0) according to neutrophillymphocyte ratio(NLR).The clinicopathological features and prognosis were compared between the two groups.Results The status of NLR was significantly correlated with gender,preoperative serum ALT level,the positivity of HbsAg and tumor gross types.The 5 year survival rate of patients in the low-NLR group was significantly better than that in the high-NLR group(31.6%vs.7.3%,P<0.05).Multivariate Cox regression analysis showed NLR level,the positivity of HbsAg and the level of ALT were independent prognostic factors in our study.Conclusion Preoperative NLR is an independent prognostic factor for cases with primary hepatocellular carcinoma underwent radical resection.