中学生童年期虐待经历与促炎因子白细胞介素-6水平的关联

Associations among childhood abuse experience and Interleukin-6 in middle school students

目的了解中学生童年期虐待的流行特征及其与促炎因子白细胞介素(IL-6)水平的关联,为深入认识童年期虐待的不良健康效应提供循证依据。方法采用整群抽样方法,于2017年12月选取沈阳市某中学911名在校生为研究对象,现场问卷调查其童年期虐待经历,收集晨起空腹血样检测IL-6水平。结果童年期虐待总体检出率为21.0%,躯体、情感和性虐待检出率分别为21.8%,20.3%,9.5%。初中男生躯体虐待、情感虐待和总虐待与高水平的IL-6相关(χ~2值分别为3.88,6.78,9.10,P值均<0.05),初中女生和高中生虐待经历与IL-6的水平相关无统计学意义。多因素Logistic回归模型结果显示,躯体虐待、情感虐待和总虐待经历与初中男生IL-6升高均呈正性相关(OR值分别为2.23,3.49,1.58,P值均<0.05)。结论童年期躯体虐待和情感虐待是初中男生IL-6水平升高的重要影响因素,炎症因子水平异常可能是初中男生童年期虐待不良健康效应的潜在基础。

Objective The present study aimed to determine the prevalence of childhood abuse and examined its correlation with inflammatory factor IL-6 level in middle schools students.Methods A total of 911 junior and high school students from a middle school in Shenyang were enrolled in this study to investigate the experience of childhood abuse and its association with IL-6 level in fasting blood samples in December 2017.Results The prevalence of childhood maltreatment was 21.0%,the prevalence of physical,emotional and sexual abuse was 21.8%,20.3%and 9.5%,respectively.Physical abuse,emotional abuse and total abuse were associated with high levels of IL-6 in junior high school boys,χ~2 values were 3.88,6.78,and 9.10,respectively(P<0.05).There was no significant correlation between abuse experiences with IL-6 levels among junior high school girls and senior high school students.Regression analysis showed that physical abuse,emotional abuse and total abuse were positively associated with IL-6 concentration among junior high school boys(OR=2.23,3.49,1.58,P<0.05).Conclusion Physical and emotional abuse in childhood associates with the increase of IL-6 level among junior school boys.Abnormal inflammatory factor level might be potential mechanism linking childhood abuse with adverse health outcomes.