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高尿酸血症的流行病学研究 被引量：84

Epidemiologic studies of hyperuricemia
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摘要 大约在1 500万年前,人类的尿酸酶基因和启动子发生系列遗传突变,导致肝脏不能将尿酸降解为尿囊素排出体外,结果使人类比其他哺乳动物(大猩猩除外)的尿酸水平更高~[1]。这种突变体现了适者生存的优势,增高的尿酸水平在人类食物中维生素C和钠含量较低时具有神经刺激剂、抗氧化剂和升高血压的作用。但是,尿酸升高提供的生存优势在人类生活水平提高及饮食结构改变后就失去了,而越来越多的研究表明.
作者 李静
机构地区 四川大学华西医院循证医学与临床流行病学教研室
出处 《中国心血管杂志》 2016年第2期83-86,共4页 Chinese Journal of Cardiovascular Medicine
关键词 高尿酸血症 流行病学研究 Hyperuricemia Epidemiologic studies
分类号 R589.7 [医药卫生—内分泌]
  • 相关文献

参考文献10

  • 1Huang H,Huang B,Li Y,et al.Uric acid and risk of heart failure:a systematic review and meta-analysis. European Journal of Heart Failure . 2014
  • 2Wang J,Qin T,Chen J,et al.Hyperuricemia and risk of incident hypertension:a systematic review and meta-analysis of observational studies. PLo S One . 2014
  • 3Peter C.Grayson,Seo YoungKim,MichaelLaValley,Hyon K.Choi.Hyperuricemia and incident hypertension: A systematic review and meta‐analysis[J].Arthritis Care Res.2010(1)
  • 4SY Kim,JP Guevara,KM Kim,HK Choi,DF Heitjan,DA Albert.Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care and Research . 2010
  • 5Huang Y,Li YL,Huang H.Effects of hyperuricemia on renal function of renal transplant recipients:a systematic review and meta-analysis of cohort studies. PLoS ONE . 2012
  • 6Min Li,Wenshang Hou,Xiaowei Zhang,Liqin Hu,Zhenyu Tang.??Hyperuricemia and risk of stroke: A systematic review and meta-analysis of prospective studies(J)Atherosclerosis . 2014 (2)
  • 7Vladimir Trkulja,Sinisa Car.On-admission serum uric acid predicts outcomes after acute myocardial infarction: systematic review and meta-analysis of prognostic studies. Croatian Medical Journal . 2012
  • 8李雨璘,王凌,李静,黄艳,袁文明.尿酸与肾脏疾病发生和预后关系的系统评价和荟萃分析[J].中华内科杂志,2011,50(7):555-561. 被引量：16
  • 9Kodama, Satoru,Saito, Kazumi,Yachi, Yoko,Asumi, Mihoko,Sugawara, Ayumi,Totsuka, Kumiko,Saito, Aki,Sone, Hirohito.??Association Between Serum Uric Acid and Development of Type 2 Diabetes(J)Diabetes Care . 2009 (9)
  • 10Xiangwei Wu,Donna M. Muzny,Cheng Chi Lee,C. Thomas Caskey.??Two independent mutational events in the loss of urate oxidase during hominoid evolution(J)Journal of Molecular Evolution . 2004 (1)

二级参考文献26

  • 1Feig DI. Uric aeid: a novel mediator and marker of risk in chronic kidney disease? Curt ()pin Nephrol Hypettens, 2009, 18: 526- 530.
  • 2Syrjanen J, Mustonen J, Pasternack A. Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy. Nephrol Dial Transplant, 2000,15:3442.
  • 3Iseki K, Oshiro S, Tozawa M,et al. Signifieanee of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res, 2001,24: 691-697.
  • 4Segura J, Campo C, Ruilope LM. How relevant and frequent is the presence of mild renal insufficiency in essential hypertension? J Clin Hypertens (Greenwich), 2002, 4: 332-336.
  • 5Tseng CH. Correlation of uric: acid and urinary albumin excretion rate in patients with type 2 diabetes mellitus in Taiwan. Kidney Int, 2005, 68:796-801.
  • 6Siu YP, Leung KT, Tong MK, et al. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis, 2006, 47:51-59.
  • 7Stehman-Breen CO, Gillen D, Steffes M, at al. Racial differences in early-onset renal disease among young adults: the coronaryartery risk development in young adults (CARDIA) study. J Am Soc Nephrol, 2003, 14: 2352-2357.
  • 8Iseki K, Ikemiya Y, lnoue T, et al. Significance of hypemricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis, 2004, 44:642-650.
  • 9Domrongkitchaiporn S, Sritara P, Kitiyakara C, et al. Risk factors for development of decreased kidney function in a southeast Asian population : a 12-year cohort study. J Am Soc Nephrol, 2005, 16 : 791-799.
  • 10Chonchol M, Shlipak MG, Katz R, et al. Relationship of uric acid with progression of kidney disease. Am J Kidney Dis, 2007, 50: 239-247.

共引文献22

同被引文献728

引证文献84

二级引证文献413

中国心血管杂志
2016年 第2期

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