2009—2013年扬州市江都区手足口病病原监测结果分析

Analysis of etiological characteristics of hand-foot-and-mouth disease in Jiangdu District of Yangzhou City from 2009 to 2013

目的分析2009-2013年杨州市江都区手足口病病原监测结果 ,初步掌握该区5年来手足口病流行特征,为该地区手足口病防治工作提供依据。方法手足口病病例肠道病毒核酸检测用荧光RT-PCR方法,检测结果用描述流行病学方法分析。结果 2009-2013年间共检测手足口病咽拭子标本458份,阳性291份,阳性率63.54%,病毒分型以EV71和Cox A16为主,分别占46.74%和35.74%。结论该区手足口病流行肠道病毒主要以EV71和Cox A16为主,重点要做好托幼机构手足口病聚集性疫情防控,加强对EV71引起的有中枢神经系统并发症的重症病例的监测,建议开展除EV71和Cox A16以外的常见肠道病毒核酸检测。

Objective To explore the epidemiological and etiologic characteristics of hand-foot-and-mouth disease(HFMD) in Jiangdu District of Yangzhou City from 2009 to 2013 so as to provide the evidence for improving the prevention and treatment of the disease. Methods The enterovirus nucleic acid of HFMD was detected with the fluo-rescence RT-PCR and the results were analyzed with the descriptive epidemiological methods. Results A total of 291 cases were enterovirus positive among 458 HFMD throat swabs tested, and the positive rate was 63.54% from 2009 to 2013.Human Enterovirus 71(EV71) and Coxsackie virus A16(Cox A16) were identified as the main pathogens of the disease accounting for 46.74% and 35.74%, respectively. Conclusion The main pathogens of HFMD are EV71 and Cox A 16 in the area. The control of aggregation epidemic of HFMD in nurseries and the surveillance of the severe patients with nervous system complications caused by EV71 should be strengthened. The nucleic acid detection of the common enterovirus except EV71 and Cox A16 are recommended.