纤维蛋白原和三酰甘油与脑小血管病血管病变关系的研究

Relationship between fibrinogen, triglyceride and vascular lesions of patients with cerebral vascular disease

目的探讨纤维蛋白原、三酰甘油与脑小血管病血管病变的关系。方法选取脑小血管病患者140例组成实验组。另选30例健康患者作为对照组。比较2组患者纤维蛋白原(FIB)、脑动脉脉动指数(PI)、CTT和三酰甘油(TG)水平并分析纤维蛋白原、三酰甘油与脑小血管病(SVD)血管病变的关系和脑小血管病血管病变的危险因素。结果实验组患者纤维蛋白原、三酰甘油水平、脑动脉脉动指数和CTT均较对照组升高,差异有统计学意义(P<0.05)Pearson相关性分析结果显示,FIB、TG与脑小血管病血管病变程度均呈正相关(rFIB=6.85,rTG=7.43,P<0.01)。多因素分析结果显示,血压、FIB和TG是脑小血管病血管病变的独立危险因素。结论脑小血管病患者纤维蛋白原和三酰甘油水平升高,纤维蛋白原和三酰甘油与脑小血管病血管病变均呈正相关,血压、纤维蛋白原和三酰甘油是脑小血管病血管病变的独立危险因素。

Objective To explore the relationship between fibrinogen, triglyceride and vascular lesions of patients with cerebral vascular disease. Methods A total of 140 patients with cerebral small vascular disease were selected as an experimental group and 30 healthy persons were chosen as a control group. The levels of fibrinogen(FIB), cerebral artery pulse index(PI), CTT and triglyceride(TG) of the two groups were assayed and the results were analyzed and compared.The risk factors for vascular lesions of patients with cerebral vascular disease and the relationship of FIB, TG and small cerebral vascular disease(SVD) were analyzed. Results The levels of FIB, TG, PI and CTT in experimental group were higher than those in the control group(P < 0.05). The Pearson analysis showed that FIB and TG were positively correlated with vascular lesions of patients with cerebral vascular disease(rFIB= 6.85, rTG= 7.43, P < 0.01). The multiple factors analysis showed that blood pressure, FIB and TG were independent risk factors of small brain vascular disease.Conclusion The levels of FIB and TG of patients with cerebral small vascular disease are increased and FIB and TG are positively correlated with vascular lesions in patients with cerebral small vascular disease. Blood pressure, FIB and TG are independent risk factors of vascular lesions in patients with cerebral small vascular disease.