灌云县正常人群甲肝免疫水平监测分析

Analysis of surveillance results of hepatitis A antibody levels among healthy population in Guanyun County

目的掌握灌云县正常人群甲肝抗体水平,评价预防接种工作质量,为进一步制订甲肝防制策略提供科学依据。方法采用酶联免疫(ELISA)法对7个不同年龄组正常人群进行甲肝血清学Ig G抗体监测,并对结果进行几何平均滴度(GMT)、χ2检验和方差分析。结果本次共检测350份血清标本,抗体阳性率为91.14%(319/350),GMT为1∶10.57。0岁组和1.5岁组抗体阳性率和GMT均较高,10岁组和20岁组则较低。结论加强甲肝疫苗基础免疫,适时对中小学生和大年龄组人群进行强化免疫,是今后控制甲肝的关键。

Objective To investigate the Hepatitis A antibody levels of healthy populations in Guanyun County, so as to provide the evidence for assessing the quality of vaccination and formulating the preventive and control strategies.Methods The Hepatitis A Ig G antibody levels were examined by ELISA in seven age-groups. The results were analyzed with GMT, χ2test and F test. Results Among the 350 serum samples, the Hepatitis A antibody positive rate was 91.14%(319/350), and the GMT was 1 ∶10.57. The antibody positive rate and GMT were higher in the 0-year-old and 1.5-year-old groups, but those were lower in the 10-year-old and 20-year-old groups. Conclusion The key of the Hep-atitis A preventive and control strategies is to strengthen basic immunization of hepatitis A vaccine and timely immunization movement in the primary and middle school students and large age group populations in the future.