女性无先兆偏头痛的流行病学及临床表现探讨

Discussion on epidemiology and clinical manifestations of woman migraine without aura

目的通过流行病学调查,分析女性无先兆偏头痛的相关因素,为女性无先兆偏头痛的防治提供理论依据。方法将女性原发性头痛的96例患者分为无先兆的月经相关性偏头痛(MRM)组、无先兆的单纯月经性偏头痛(PMM)组、月经性无先兆偏头痛(NMM)组共3个组,观察患者的一般资料,包括年龄、病程(年)、家族史(直系亲属);头痛性质:头痛的严重程度、发作频率、持续时间;共病(情绪改变)及伴随症状。所得数据用SPSS15.0软件包进行统计,计数资料行χ2检验,计量资料行t检验,多个组间比较采用单因素方差分析。结果⑴MRM组、PMM组患者家族史阳性率高于NMM组,差异有统计学意义(χ2=10.541,P<0.01),MRM组、PMM组患者重度疼痛阳性率高于NMM组,差异有统计学意义(χ2=9.264,P<0.05);⑵MRM组和PMM组头痛程度VAS评分、持续时间均高/长于NMM组(P<0.05),NMM组患者发作频率低于MRM组发作频率(P<0.01)。结论女性月经性偏头痛患者家族史、重度疼痛阳性率及疼痛程度、发作频率,持续时间高/长于非月经性头痛,对指导女性无先兆偏头痛的防治有重要意义。

Objective To investigate the factors related to woman migraine without aura, so as to provide the reference for improving the prevention and treatment of woman migraine without aura. Methods A total of 96 female cases of primary headache were divided into a MRM group, PMM group and NMM group. The general data of the patients were collected, including the age, duration(year), family history(immediate family);headache(the severity of headache, onset frequency, duration);co-morbidity(mood change) and concomitant symptoms. The data were analyzed by SPSS 15.0 software package. Results(1)The positive rates of family history of the MRM and PMM groups were significantly higher than that of the NMM group(χ~2=10.541, P < 0.01), and the positive rates of severe pain of the MRM and PMM groups was significantly higher than that of the NMM group,(χ~2=9.264,P<0.05).(2) The VAS scores of headache and the time of duration of the MRM and PMM groups were higher/longer than those of the NMM group(P < 0.05), while the frequency of the NMM group was lower than that of the MRM group(P < 0.01). Conclusion The family history of menstrual migraine in women, the positive rate of severe pain, the degree of pain, the frequency of seizures, and the duration of seizures are higher/longer than those of non-menstrual headaches, which is of great significance to guide the prevention and treatment of women migraine without aura.