摘要
目的 :探讨半夏泻心汤及其拆方对应激性胃溃疡的作用机理。方法 :采用水浸 束缚应激造成大鼠急性胃溃疡模型 ,观察半夏泻心汤及其拆方各组对其治疗作用及其对P物质(SP)的影响 ,为半夏泻心汤配伍规律的探讨提供科学实验研究的参照。结果 :与正常组相比 ,模型组SP的表达明显增强。半夏泻心汤全方及各拆方组可以通过下调SP的表达体现出治疗作用 ,其中甘补药组下调作用最为明显 ,苦降药组其次 ,辛开药组作用最弱 ,两两配合后的作用表现出复杂性 ,虽然下调作用减弱 ,但综合治疗作用增强。
Objective: To explore the mechanism of actions of Banxia Xiexin Decoction and its broken prescriptions on gastric stress ulcer. Methods: The acute gastric stress ulcer model in rat was established by applying water immersion-restraint stress, and then the therapeutic effects of the decoctions on the model and SP in model rats were observed. This experiment provides a scientific and experimental reference for the discussion on the compatibility law of Banxia Xiexin Decoction. Results: Compared to control group, the expression of SP increased in model group. The full Banxia Xiexin Decoction and its broken prescriptions can embody their therapeutic actions by down regulating the SP expression. The actions of the prescriptions in sequence from the strongest to weakest are the group dealt with sweet tonifying herbs, the group with bitter purgative herbs and the group with pungent dispersing herbs. Conclusi the paired combinations of different herbs with different natures and functions have complexity, which decreases the down regulating ability, but the combinations were of increased synthetic therapeutic effects.
出处
《中国医药学报》
CSCD
2003年第11期669-671,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京中医药大学"2 11工程"国家级重点学科建设项目