血清碱性磷酸酶与骨折愈合的相关性分析

Analysis of Correlation on Serum Alkaline Phosphatase and Fracture Healing

目的:探讨成人骨折患者血清碱性磷酸酶(ALP)的活性与骨折愈合的相关性。方法:分别检测73例骨折患者及软组织损伤患者外伤发生后1周、2周、3个月、8个月及12个月ALP水平;选取软组织损伤组为对照组,以骨折组为观察组,对照组及观察组均于伤后1周内摄x线片,而观察组于骨折2周、3个月、8个月、12个月摄x线片观察骨折愈合情况,由高级职称的放射科医师及骨科医师对骨折愈合情况进行比较评价,包括骨痂的形成量和骨折线的变化;同时,检测对照组和观察组1周、2周、3个月、8个月及12个月ALP水平。结果:观察组在骨折发生后2周开始至骨折愈合均较对照组ALP水平高,P<0.01,有显著性差异。结论:骨折患者监测血清ALP水平可对骨折愈合情况作出早期判断,为临床治疗提供依据。

Objective:To explore the relation from adult patients with fracture between serum alkaline phosphatase(ALP) activity and fracture healing. Methods:To detect ALP level from 146 cases of fracture patients and patients with injury of soft tissue after trauma at the first week,the second week,the third month,the eighth month and the twelfth month. Soft tissue injury group was to be the control group,fracture group was to be the observation group.The observation group and the control group were taken X-ray within 1 week after injury,while the observation group was taken X-ray to observe fracture healing at the second week,the third month,the eighth month and the twelfth month. Formation of callus and the change of the fracture line were evaluated by senior radiologists and orthopedic surgeon and the ALP level of the control group and the observation group was detected at the first week,the second week,the third month,the eighth month and the twelfth month. Results:Observation group after the fracture had higher ALP level than control group from the second week to fracture healing,p﹤ 0.01,there was a significant difference between two groups. Conclusion:monitor serum ALP level can make the early estimate and provide the basis for clinical treatment of fracture patients.